39203-20-8 Usage
Description
N-(Methoxycarbonyl)indole, also known as Indole-1-carboxylic acid methyl ester, is an organic compound derived from the indole family. It is characterized by the presence of a methoxycarbonyl group and a methyl ester group, which contribute to its unique chemical properties and reactivity.
Uses
N-(Methoxycarbonyl)indole, Indole-1-carboxylic acid methyl ester is used as a reactant in various chemical synthesis processes for the development of different compounds and materials.
Used in Pharmaceutical Industry:
N-(Methoxycarbonyl)indole, Indole-1-carboxylic acid methyl ester is used as a reactant for the preparation of Bcl Inhibitor Obatoclax. This application is significant because Obatoclax is a potent inhibitor of the anti-apoptotic Bcl-2 protein family, which plays a crucial role in the development and progression of various cancers.
Used in Organic Synthesis:
N-(Methoxycarbonyl)indole, Indole-1-carboxylic acid methyl ester is used as a reactant for the preparation of tetracyclic indolines. These complex indole-based structures are valuable in the synthesis of various bioactive compounds, including pharmaceuticals and agrochemicals.
Used in Friedel-Crafts Alkylation:
N-(Methoxycarbonyl)indole, Indole-1-carboxylic acid methyl ester is used as a reactant for Friedel-Crafts alkylation reactions of indoles. This versatile reaction allows for the introduction of alkyl groups to the indole nucleus, leading to the formation of a wide range of indole-based compounds with diverse applications in the chemical and pharmaceutical industries.
Used in Oxidative Free Radical Reactions:
N-(Methoxycarbonyl)indole, Indole-1-carboxylic acid methyl ester is used as a reactant for oxidative free radical reactions. These reactions are essential in the synthesis of various indole-based compounds with modified properties, which can be utilized in different applications, such as the development of new materials, pharmaceuticals, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 39203-20-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,2,0 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 39203-20:
(7*3)+(6*9)+(5*2)+(4*0)+(3*3)+(2*2)+(1*0)=98
98 % 10 = 8
So 39203-20-8 is a valid CAS Registry Number.
39203-20-8Relevant articles and documents
Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of o-Allenyl Anilines
Lauta, Nicholas R.,Williams, Ryan E.,Smith, David T.,Kumirov, Vlad K.,Njardarson, Jon T.
, p. 10713 - 10723 (2021/07/31)
A new intramolecular oxidative amino-hydroxylation of o-allenyl anilines is reported. Treatment of carbamate-protected anilines with lead(IV) carboxylates in dichloromethane at room temperature results in facile tandem C-N (allene cyclization) and C-O bon
Synthesis of indolylindolines mediated by t-BuNH2
Suarez-Castillo, Oscar R.,Melendez-Rodriguez, Myriam,Morales-Garcia, Ana L.,Cano-Escudero, Indira C.,Contreras-Martinez, Yaneth M.A.,Morales-Rios, Martha S.,Joseph-Nathan, Pedro
experimental part, p. 1463 - 1476 (2009/12/24)
An improved synthesis of N1-carbomethoxylated indolylindolines 2 from 5-substituted indoles 1, by replacing the previously employed strong acids or toxic metals with t-BuNH2/MeOCOCl in CH2Cl2/H2O, is described.
