39213-22-4

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE
• Synonyms: 3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE;3,5-BIS(TRIFLUOROMETHYL)BENZENE SULPHONAMIDE;BUTTPARK 44\03-72
• CAS NO: 39213-22-4
• Molecular Formula: C₈H₅F₆NO₂S
• Molecular Weight: 293.19
• Mol File: 39213-22-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 180-182°C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE(39213-22-4)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE(39213-22-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 39213-22-4(Hazardous Substances Data)

Usage

General Description

3,5-Bis(trifluoromethyl)benzenesulfonamide, also known as TFBSA, is a chemical compound with the molecular formula C8H6F6NO2S. It is a white crystalline solid that is commonly used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. TFBSA is highly stable and non-reactive under normal conditions, making it a valuable additive in various industries. It is also used as a ligand in coordination chemistry and as a protecting group in peptide synthesis. TFBSA exhibits strong electron-withdrawing properties due to the presence of trifluoromethyl groups, making it a versatile and important chemical in a wide range of applications.

Upstream product

• 39234-86-1 3,5-bis(trifluoromethyl)benzenesulfonyl chloride 
• 7440-44-0 pyrographite 

Downstream Products

• 512818-39-2 4-(3,5-bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1165944-33-1 N-((2E,5E)-hepta-2,5-dienyl)-3,5-bis(trifluoromethyl)benzenesulfonamide 
• 1165944-26-2 (E)-N-(3-cyclohexylallyl)-3,5-bis(trifluoromethyl)benzenesulfonamide 
• 1610050-47-9 C₃₆H₃₁F₆NO₂P₂S 
• 1610050-45-7 C₃₂H₂₃F₆NO₂P₂S 
• 1338799-21-5 (S)-N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-pyrrolidine-2-carboxamide 
• 1287189-58-5 N₁-(3,5-bis(trifluoromethyl)phenyl)-N₃-(3,5-bis(trifluoromethyl)phenylsulfonyl)benzene-1,3-dicarboxamide 
• 1176325-58-8 C₁₇H₁₄F₆INO₂S 
• 512821-99-7 1-[2-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-1-(4-chloro-phenyl)-2-oxo-ethyl]-piperidine-4-carboxylic acid cyclohexylamide 
• 512820-66-5 2-{4-[2-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-2-oxo-ethyl]-piperidin-1-yl}-4-trifluoromethyl-benzamide 
• 512820-46-1 10-(3,5-bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-8-aza-bicyclo[4.3.1]decane-8-carboxylic acid tert-butyl ester 

Relevant articles and documents

A recyclable and highly stereoselective multi-fluorous proline catalyst for asymmetric aldol reactions

A recyclable fluorous proline catalyst with high stereoselectivity that functions as a catalyst for asymmetric aldol reactions is described. Its high stereoselectivity and facile recovery are achieved by employing a multi-fluorous tag attachment strategy. Although a gradual decrease was observed with respect to the catalytic activity, the catalyst can be separated from the reaction mixture by adsorption onto FluoroFlash and can be reused in that form for a maximum of five times while maintaining a high stereoselectivity.2019 Elsevier Ltd. All rights reserved.

Synthesis and NMR binding studies towards rational design of a series of electron-withdrawing diamide receptors/organocatalysts

A related series of bisamides have been evaluated for rational correlation between anion complexation and organocatalysis: remarkable enhancement of hydrogen bonding to anions was observed along with significant increases in catalytic activity in the Bayl

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