39214-83-0

Basic information

• Product Name: 3-(4-NITROPHENYL)-5(4H)-ISOXAZOLONE
• Synonyms: 3-(4-NITROPHENYL)-5(4H)-ISOXAZOLONE;3-(4-nitrophenyl)isoxazol-5(4H)-one
• CAS NO: 39214-83-0
• Molecular Formula: C₉H₆N₂O₄
• Molecular Weight: 206.15
• Mol File: 39214-83-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-NITROPHENYL)-5(4H)-ISOXAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-NITROPHENYL)-5(4H)-ISOXAZOLONE(39214-83-0)
• EPA Substance Registry System: 3-(4-NITROPHENYL)-5(4H)-ISOXAZOLONE(39214-83-0)

Safety Data

• Hazardous Substances Data: 39214-83-0(Hazardous Substances Data)

Upstream product

• 619-50-1 4-nitrobenzoic acid methyl ester 
• 59156-55-7 methyl 3-(4-nitrophenyl)-3-oxopropanoate 
• 99-77-4 ethyl 4-nitrobenzoate 
• 838-57-3 ethyl 4-nitrobenzoylacetate 
• 91135-90-9 4-acetyl-3-(4-nitro-phenyl)-2H-isoxazol-5-one 

Downstream Products

• 25755-90-2 5-methoxy-3-(4-nitrophenyl)isoxazole 
• 46992-58-9 5-chloro-2-(4-nitrophenyl)-1H-benzo[d]imidazole 
• 139436-67-2 6-Chloro-2-(4-nitro-phenyl)-quinoxaline 
• 2818-69-1 5-chloro-2-methyl-1H-benzimidazole 
• 142335-36-2 7-Chloro-4-(4-nitro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 108471-52-9 5-chloro-3-(4-nitrophenyl)isoxazole-4-carbaldehyde 
• 25755-92-4 methyl 3-(4-nitrophenyl)-2H-azirine-2-carboxylate 
• 267877-41-8 2-acetyl-3-(4-nitrophenyl)isoxazol-5(2H)-one 
• 1772-39-0 5-nitro-2-(4-nitrophenyl)-1H-benzimidazole 
• 35043-12-0 7-nitro-2-(4-nitro-phenyl)-quinoxaline 
• 1792-40-1 2-methyl-5-nitrobenzimidazole 
• 142335-39-5 8-Nitro-4-(4-nitro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 76148-57-7 3,3'-Bis-(4-nitro-phenyl)-2H,2'H-[2,2']bi[benzo[1,4]thiazinyl] 
• 729-13-5 2-(4-nitrophenyl)benzimidazole 

Relevant articles and documents

Atom-Economic Silver-Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones

An unprecedented silver-catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom-economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late-stage modification of a few biologically active molecules.

Synthesis of novel isoxazole fused heterocycles

Condensation of 3-aryl-4-formyl isoxazoles with 1,2-diamines led to the formation of 3-aryl-(6,7-benzo-1,5-heptadiazino)(3,2-d)-isoxazoles or isoxazolo-[5,4-b]-benzodiazepines and 3,10-diaryl-6,7,14,15-tetrhydro-13 H,16H-diisoxazole-(4,5-b;4,5-l)(1,4,8,11)-tetra-aza-cyclo-tetra-deca-4, 14-diones, the novel seven-and 14-membered heterocyclic systems. Similar compounds are of great importance in medicinal chemistry.

Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon

Unsubstituted and 7- or 8-substituted 4-aryl-1H-1,5-benzodiazepin-2(3H)-ones 3a-t have been synthesized by the condensation of 3-aryl-5(4H)-isoxazolones 1a-e and parent 4-substituted 1,2-benzenediamines 2a-d under acidic conditions.