39232-03-6

Basic information

• Product Name: 4-(2-bromoethyl)aniline
• Synonyms: 4-(2-bromoethyl)aniline;4-(2-broMoethyl)aniline hydrochloride
• CAS NO: 39232-03-6
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Mol File: 39232-03-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 277.6°Cat760mmHg
• Flash Point: 121.7°C
• Appearance: /
• Density: 1.452g/cm³
• Vapor Pressure: 0.00448mmHg at 25°C
• Refractive Index: 1.61
• PKA: 4.65±0.10(Predicted)
• CAS DataBase Reference: 4-(2-bromoethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-bromoethyl)aniline(39232-03-6)
• EPA Substance Registry System: 4-(2-bromoethyl)aniline(39232-03-6)

Safety Data

• Hazardous Substances Data: 39232-03-6(Hazardous Substances Data)

Usage

Physical state

Pale yellow to brownish liquid

Classification

Halogenated aromatic amine

Common uses

Production of dyes, pharmaceuticals, and other organic compounds

Applications

Synthesis of various organic compounds, production of agricultural chemicals, pharmaceuticals, and dyes

Safety precautions

Handling and use should be done with appropriate safety measures in a well-ventilated environment

InChI:InChI=1/C8H10BrN/c9-6-5-7-1-3-8(10)4-2-7/h1-4H,5-6,10H2

Upstream product

• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 149068-81-5 1-azido-4-(2-bromoethyl)benzene 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 

Downstream Products

• 115519-20-5 trans-4-(2-bromoethyl)-1-trifluoromethoxybenzene 
• 218943-57-8 1-(2-bromoethyl)(4-t-butoxycarbonylamino)benzene 
• 864529-66-8 N-[4-(2-azidoethyl)phenyl]acetamide 
• 1346427-62-0 C₁₃H₁₀Br₃N₇O₂ 
• 1346427-54-0 C₁₁H₇Br₃N₄ 
• 1346427-48-2 C₁₁H₉Br₃N₄O 
• 1346427-43-7 C₁₁H₁₀Br₃N₅O 
• 1346427-39-1 C₈H₆Br₃N₃ 
• 39232-06-9 2-bromo-1-[4-(acetylamino)phenyl]-ethane 
• 1118752-49-0 C₁₇H₂₁N₇ 
• 1118752-48-9 C₁₉H₂₅N₇ 
• 1118752-47-8 C₁₉H₂₅N₇ 

Relevant articles and documents

Silver nanoparticles supported on P, Se-codoped g-C3N4 nanosheet as a novel heterogeneous catalyst for reduction of nitroaromatics to their corresponding amines

P, Se-codoped g-C3N4 (PSeCN) nanosheet was in situ prepared by facile thermal polymerization of melamine, phosphonitrilic chloride trimer, and selenium black powder as the precursors. It was found as a suitable support for the immobilization of silver nanoparticles (Ag NPs). The prepared nanocatalyst was fully characterized via standard analysis methods including EDX, ICP-OES, XRD, FT-IR, SEM, TEM, and BET. This PSeCN/Ag nanocatalyst with a higher specific surface area compared with CN, showed excellent catalytic activity towards the reduction of several nitroaromatic compounds using sodium borohydride (NaBH4) in short reaction times with high efficiency and good selectivity in water as a green solvent. Significantly, the above-mentioned nanocomposite could be reused six times without appreciable loss of its catalytic activity.

Rapid and convenient conversion of nitroarenes to anilines under microwave conditions using nonprecious metals in mildly acidic medium

Nitroarenes are reduced to the corresponding aniline derivatives using iron or zinc under mild conditions under microwave heating conditions. Mild acidity is provided by ammonium chloride in an aqueous methanol medium. The conditions are tolerant to other functional groups, with the exception of bromoalkyl derivatives, which yield complex reaction mixtures; otherwise, yields are generally quite high (80–99%).

Synthesis and docking of novel piperidine renin inhibitors

A series of 4-triazolyl-substituted piperidine derivatives were synthesized from N-Boc protected trans-4-ethynyl-3-hydroxypiperidine and tested as novel renin inhibitors. Piperidine derivatives containing a 1-substituted 1,2,3-triazol-5-yl substituent were found to be most active. Molecular docking experiments provide a rank order that is in agreement with experimental data. Furthermore, all compounds explore the S1 and the S3 subpockets through the piperidine substituents.