392328-26-6 Usage
Description
(3S,4R)-(-)-N-benzyloxycarbonyl-4-(4'-fluorophenyl)-3-hydroxyMethylpiperidine is a complex piperidine derivative featuring a benzyl carbamate group, a hydroxymethyl group, and a fluorophenyl group. This chemical compound holds potential in organic synthesis and medicinal chemistry due to its unique molecular structure.
Uses
Used in Organic Synthesis:
(3S,4R)-(-)-N-benzyloxycarbonyl-4-(4'-fluorophenyl)-3-hydroxyMethylpiperidine is used as a building block for the synthesis of various organic molecules, leveraging its unique structure to create a range of compounds with different properties and applications.
Used in Medicinal Chemistry:
In the pharmaceutical industry, (3S,4R)-(-)-N-benzyloxycarbonyl-4-(4'-fluorophenyl)-3-hydroxyMethylpiperidine is used as a starting material for the development of new pharmaceutical substances. Its potential therapeutic effects are being explored, with further research and testing required to fully understand its characteristics and applications in drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 392328-26-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,2,3,2 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 392328-26:
(8*3)+(7*9)+(6*2)+(5*3)+(4*2)+(3*8)+(2*2)+(1*6)=156
156 % 10 = 6
So 392328-26-6 is a valid CAS Registry Number.
392328-26-6Relevant articles and documents
Enzymatic alkoxycarbonylation reactions on the intermediate in the synthesis of (-)-paroxetine, trans-N-benzyloxycarbonyl-4-(4′-fluorophenyl)-3-hydroxymethylpiperidine
De Gonzalo, Gonzalo,Brieva, Rosario,Sanchez, Victor M.,Bayod, Miguel,Gotor, Vicente
, p. 1725 - 1731 (2007/10/03)
Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans-N-benzyloxycarbonyl-4-(4′-fluorophenyl)-3- hydroxymethylpiperidine, a chiral intermediate in the synthesis of (-)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with diallylcarbonate with high enantioselectivity.
Piperidine derivative and process for preparing the same
-
, (2008/06/13)
A piperidine derivative, which can be used as an intermediate for pharmaceuticals such as paroxetine useful as antidepressants, represented by the general formula (I): STR1 wherein R1 is hydrogen atom, benzyloxycarbonyl group or tert-butoxycarbonyl group; R2 is hydroxymethyl group, an alkylsulfonyloxymethyl group having an alkyl moiety of 1 to 2 carbon atoms, phenylsulfonyloxymethyl group which may have methyl group at the 4-position, (3,4-methylenedioxyphenyl)oxymethyl group, carboxyl group or --CO2 R7 group in which R7 is an alkyl group having 1 to 5 carbon atoms, and Z is methylene group or carbonyl group.
