39257-91-5

Basic information

• Product Name: 1-(4-NITRO-PHENYL)-PIPERIDIN-2-ONE
• Synonyms: 1-(4-NITRO-PHENYL)-PIPERIDIN-2-ONE
• CAS NO: 39257-91-5
• Molecular Formula: C₅H₁₀O₂S
• Molecular Weight: 220.22458
• Mol File: 39257-91-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-NITRO-PHENYL)-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITRO-PHENYL)-PIPERIDIN-2-ONE(39257-91-5)
• EPA Substance Registry System: 1-(4-NITRO-PHENYL)-PIPERIDIN-2-ONE(39257-91-5)

Safety Data

• Hazardous Substances Data: 39257-91-5(Hazardous Substances Data)

Usage

General Description

1-(4-Nitro-phenyl)-piperidin-2-one is a chemical compound with the molecular formula C11H12N2O3. It is a piperidinone derivative that contains a nitrophenyl group attached to the piperidinone ring. 1-(4-NITRO-PHENYL)-PIPERIDIN-2-ONE has applications in organic synthesis and medicinal chemistry research, as it can be used as a building block for the synthesis of various pharmacologically active compounds. Additionally, it has been studied for its potential biological activities, including its antiviral and antimicrobial properties, and its ability to inhibit certain enzymes. The compound should be handled and used with care, as it has potential hazards associated with its toxicity and reactivity.

Upstream product

• 1003-10-7 Thiobutyrolactone 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 1192482-03-3 C₃₁H₅₄O₄Si₂ 
• 220280-99-9 methyl 4-S-(3-O'-allyl-2-O'-acetyl-6-O'-tert-butyldiphenylsilyl-β-D-galactopyranosyl)mercaptobutyrate 
• 220280-95-5 methyl 4-S-(2-O'-acetyl-6-O'-tert-butyldiphenylsilyl-3,4-O'-isopropylidene-β-D-galactopyranosyl)mercaptobutyrate 
• 220280-97-7 methyl 4-S-(2-O'-acetyl-6-O'-tert-butyidiphenyisilyl-β-D-galacto-pyranosyl)mercaptobutyrate 
• 220280-93-3 4-[(3aS,4R,6S,7R,7aR)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-7-hydroxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ylsulfanyl]-butyric acid methyl ester 
• 220280-89-7 methyl 4-S-(6-O'-tert-butyldiphenylsilyl-beta-D-galactopyranosyl)mercaptobutyrate 
• 928625-17-6 4-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanyl]-butyric acid methyl ester 
• 904916-19-4 (+/-) methyl 4-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]butyrate 
• 307556-83-8 methyl 4-(2-formylphenylthio)butyrate 
• 109695-59-2 4,4'-p-xylylenedisulfonyl-di-butyric acid dimethyl ester 

Relevant articles and documents

STUDIES DIRECTED TOWARDS THE TOTAL SYNTHESIS OF DICYCLOPENTACYCLOOCTANE TERPENOIDS.

A general strategy for the synthesis of dicyclopentacyclooctane terpenoids is reported.Compound 1 was synthesized from 3-methoxycarbonyl-2-cyclopentenone; its photocycloaddition led to four diastereoisomeric photoadducts whose structure were determined by X-ray analysis, 1H-NMR data and chemical transformations.

MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS

Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Solid-phase synthesis of thermolytic DNA oligonucleotides functionalized with a single 4-hydroxy-1-butyl or 4-phosphato-/thiophosphato-1-butyl thiophosphate protecting group

(Chemical Equation Presented) Several thermolytic CpG-containing DNA oligonucleotides analogous to 1 have been synthesized to serve as potential immunotherapeutic oligonucleotide prodrug formulations for the treatment of infectious diseases in animal models. Specifically, the CpG motif (GACGTT) of each DNA oligonucleotide has been functionalized with either the thermolabile 4-hydroxy-1-butyl or the 4-phosphato-/thiophosphato-1-butyl thiophosphate protecting group. This functionalization was achieved through incorporation of activated deoxyribonucleoside phosphoramidite 8b into the oligonucleotide chain during solid-phase synthesis and, optionally, through subsequent phosphorylation effected by phosphoramidite 9. Complete conversion of CpG ODNs hbu1555, psb1555, and pob1555 to CpG ODN 1555 (homologous to 2) occurred under elevated temperature conditions, thereby validating the function of these diastereomeric oligonucleotides as prodrugs in vitro. Noteworthy is the significant increase in solubility of CpG ODN psb1555 and CpG pob1555 in water when compared to that of neutral CpG ODN fma1555 (homologous to 1).