392718-69-3

Basic information

• Product Name: (1-Acetoxy-2,2,5,5-tetramethyl-d-3-pyrroline-3-methyl) Methanethiosulfonate
• Synonyms: (1-Acetoxy-2,2,5,5-tetramethyl-δ-3-pyrroline-3-methyl) Methanethiosulfonate;Acetic Acid 2,5-Dihydro-2,2,5,5-tetraMethyl-3-[[(Methylsulfonyl)thio]Methyl]-1H-pyrrol- 1-yl Ester;Methanesulfonothioic Acid S-[[1-(Acetyloxy)-2,5-dihydro-2,2,5,5- tetraMethyl-1H-pyrrol-3-yl]Methyl] Ester
• CAS NO: 392718-69-3
• Molecular Formula: C12H21NO4S2
• Molecular Weight: 307.433
• Product Categories: MTS and Sulfhydryl Active Reagents;MTS & Sulfhydryl Active Reagents;Heterocycles;Sulfur & Selenium Compounds;Heterocycles, MTS & Sulfhydryl Active Reagents, Sulfur & Selenium Compounds
• Mol File: 392718-69-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 59-60°C
• Boiling Point: 408.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: -0.98±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: (1-Acetoxy-2,2,5,5-tetramethyl-d-3-pyrroline-3-methyl) Methanethiosulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Acetoxy-2,2,5,5-tetramethyl-d-3-pyrroline-3-methyl) Methanethiosulfonate(392718-69-3)
• EPA Substance Registry System: (1-Acetoxy-2,2,5,5-tetramethyl-d-3-pyrroline-3-methyl) Methanethiosulfonate(392718-69-3)

Safety Data

• Hazardous Substances Data: 392718-69-3(Hazardous Substances Data)

Usage

Description

(1-Acetoxy-2,2,5,5-tetramethyl-d-3-pyrroline-3-methyl) Methanethiosulfonate, also known as MTSL, is a highly reactive thiol-specific spin-label analogue. It is a light yellow solid that is commonly used in various applications due to its unique chemical properties.

Uses

Used in Chemical Research:
MTSL is used as a spin-labelling agent for studying the structure and dynamics of biomolecules, particularly proteins. Its thiol-specific reactivity allows for the selective labeling of cysteine residues, providing valuable insights into protein folding, conformational changes, and interactions with other molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, MTSL is employed as a tool for drug discovery and development. Its ability to modify cysteine residues can be utilized to investigate the structure-activity relationships of drug candidates and to develop novel therapeutic agents with improved properties.
Used in Diagnostic Applications:
MTSL can be used as a diagnostic tool in the detection and monitoring of various diseases and conditions. Its unique reactivity with thiol groups can be exploited to develop assays for the detection of specific biomarkers or to study the role of cysteine residues in disease-related proteins.
Used in Material Science:
In material science, MTSL can be used to modify the properties of polymers and other materials. Its ability to react with thiol groups can be employed to create new materials with tailored properties, such as improved stability, enhanced reactivity, or altered mechanical characteristics.