3929-47-3

Basic information

• Product Name: 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL
• Synonyms: Benzenepropanol, 3,4-dimethoxy-;3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL;3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL;3-(3,4-dimethoxyphenyl)propanol;3-(3,4-Dimethoxyphenyl)propyl alcohol;3,4-Dimethoxybenzene-1-propanol
• CAS NO: 3929-47-3
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24
• EINECS: 223-499-9
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 3929-47-3.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 142-144 °C0.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.081 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.82E-05mmHg at 25°C
• Refractive Index: n20/D 1.54(lit.)
• CAS DataBase Reference: 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL(3929-47-3)
• EPA Substance Registry System: 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL(3929-47-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3929-47-3(Hazardous Substances Data)

Usage

Description

3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL is an organic compound characterized by its chemical structure that features a propanol backbone with a 3,4-dimethoxyphenyl group attached to it. This molecule is known for its potential applications in various industries due to its unique properties.

Uses

Used in Pharmaceutical Industry:
3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL is used as an intermediate compound for the synthesis of various pharmaceuticals, specifically in the production of fluorinated benzamide neuroleptic. The expression is: 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL is used as a synthetic intermediate for the creation of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-fluoropropyl)-2,3-dimethoxybenzamide, which is a neuroleptic agent with potential applications in the treatment of various neurological and psychiatric disorders.

InChI:InChI=1/C11H16O3/c1-13-10-6-5-9(4-3-7-12)8-11(10)14-2/h5-6,8,12H,3-4,7H2,1-2H3

Upstream product

• 5462-13-5 ethyl 3-(3,4-dimethoxyphenyl)propionate 
• 2107-70-2 3,4-methoxycinnamic acid 
• 40918-90-9 3'-Hydroxymethyleugenol 
• 27798-73-8 methyl 3-(3,4-dimethoxyphenyl)propionate 
• 61871-67-8 3-(3,4-Dimethoxyphenyl)propanal 
• 6258-35-1 3-(3,4-dimethoxyphenyl)prop-2-yn-1-ol 
• 18523-76-7 (E)-3',4'-dimethoxycinnamyl alcohol 
• 70570-23-9 (Z)-3-(3,4-dimethoxyphenyl)-2-propen-1-ol 
• 58045-88-8 3,4-dimethoxycinnamaldehyde 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 2859-78-1 4-Bromoveratrole 
• 100157-47-9 3-(3,4-dimethoxyphenyl)-1,1-ethylendioxypropane 

Downstream Products

• 20716-22-7 3-(4,5-dimethoxy-2-nitrophenyl)propan-1-ol 
• 3945-85-5 1-bromo-3-(3,4-dimethoxyphenyl)propane 
• 97465-82-2 (2S,3R)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-5-[(E)-3-hydroxy-1-propenyl]-3-hydroxymethyl-7-methoxybenzo[b]furan 
• 215319-47-4 (E)-3-[(2S,3R)-2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-1-benzo[b]furan-5-yl]-2-propenal 
• 62359-60-8 lappaol B 
• 70821-95-3 1-(bromomethyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin 
• 79242-33-4 4-[3-(2-Bromo-1-ethoxy-ethoxy)-propyl]-1,2-dimethoxy-benzene 
• 70822-11-6 2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate 
• 74539-12-1 2-[2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)methoxy]ethyl]aminoethanol 
• 70821-80-6 1-[2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)methoxy]ethyl]-4-(4-fluorophenyl)-piperazine 
• 70821-76-0 1-[2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)methoxy]ethyl]-4-(2-methoxyphenyl)-piperazine 
• 314741-29-2 1-[3-(3,4-Dimethoxyphenyl)-propyl]-4-[2-(R,S)-hydroxy-2-(6-methoxyquinolin-4-yl)ethyl]piperazine 
• 1204428-33-0 C₁₆H₂₄O₃ 
• 1204428-32-9 4-(3-(cyclopropylmethoxy)propyl)-1,2-dimethoxybenzene 

Relevant articles and documents

DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE

Described herein are small molecule agonists of dopamine receptor D1 that inhibit YAP/TAZ, compositions, and methods of using these compounds and compositions.

Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)?H/C(sp)?H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands

The intermolecular asymmetric radical oxidative C(sp3)?C(sp) cross-coupling of C(sp3)?H bonds with readily available terminal alkynes is a promising method to forge chiral C(sp3)?C(sp) bonds because of the high atom and step economy, but remains underexplored. Here, we report a copper-catalyzed asymmetric C(sp3)?C(sp) cross-coupling of (hetero)benzylic and (cyclic)allylic C?H bonds with terminal alkynes that occurs with high to excellent enantioselectivity. Critical to the success is the rational design of chiral oxazoline-derived N,N,P(O)-ligands that not only tolerate the strong oxidative conditions which are requisite for intermolecular hydrogen atom abstraction (HAA) processes but also induce the challenging enantiocontrol. Direct access to a range of synthetically useful chiral benzylic alkynes and 1,4-enynes, high site-selectivity among similar C(sp3)?H bonds, and facile synthesis of enantioenriched medicinally relevant compounds make this approach very attractive.

Cleavage of aryl-ether bonds in lignin model compounds using a Co-Zn-beta catalyst

Efficient cleavage of aryl-ether linkages is a key strategy for generating aromatic chemicals and fuels from lignin. Currently, a popular method to depolymerize native/technical lignin employs a combination of Lewis acid and hydrogenation metal. However, a clear mechanistic understanding of the process is lacking. Thus, a more thorough understanding of the mechanism of lignin depolymerization in this system is essential. Herein, we propose a detailed mechanistic study conducted with lignin model compounds (LMC) via a synergistic Co-Zn/Off-Al H-beta catalyst that mirrors the hydrogenolysis process of lignin. The results suggest that the main reaction paths for the phenolic dimers exhibiting α-O-4 and β-O-4 ether linkages are the cleavage of aryl-ether linkages. Particularly, the conversion was readily completed using a Co-Zn/Off-Al H-beta catalyst, but 40% of α-O-4 was converted and β-O-4 did not react in the absence of a catalyst under the same conditions. In addition, it was found that the presence of hydroxyl groups on the side chain, commonly found in native lignin, greatly promotes the cleavage of aryl-ether linkages activated by Zn Lewis acid, which was attributed to the adsorption between Zn and the hydroxyl group. Followed by the cobalt catalyzed hydrogenation reaction, the phenolic dimers are degraded into monomers that maintain aromaticity. This journal is