393-09-9 Usage
Description
5-Fluoro-2-nitrobenzotrifluoride is a tri-substituted benzene derivative formed by the nitration of m-fluorobenzotrifluoride. It is a clear yellow liquid after melting and is known for its versatile applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
5-Fluoro-2-nitrobenzotrifluoride is used as a key intermediate in the synthesis of androgen receptor modulators and other pharmaceutical compounds. Its unique chemical structure allows for the development of novel therapeutic agents that can target specific receptors in the body, potentially leading to more effective treatments for various medical conditions.
Used in Chemical Synthesis:
5-Fluoro-2-nitrobenzotrifluoride serves as a monomer in the synthesis of hyperbranched poly(aryl ether). This polymer has potential applications in various fields due to its unique properties, such as its ability to form complex structures and its potential use in advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 393-09-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 393-09:
(5*3)+(4*9)+(3*3)+(2*0)+(1*9)=69
69 % 10 = 9
So 393-09-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H3F4NO2/c8-4-1-2-6(12(13)14)5(3-4)7(9,10)11/h1-3H
393-09-9Relevant articles and documents
Development of nonsteroidal antiandrogens: 4-Nitro-3-trifluoro-methyldiphenylamines
Humm,Schneider
, p. 83 - 87 (2007/10/02)
For the development of new nonsteroidal antiandrogens a series of 4-nitro-3-trifluoromethyldiphenylamines was synthesized and compounds were tested for their affinities to steroid hormone receptors and for antiandrogenic activities. These compounds were synthesized by reacting 4-nitro-3-trifluoromethylphenylsulfocyanamide-sodium (4) with the corresponding aromatic amines to give the N-(4-nitro-3-trifluoromethylphenylsulfonyl)-N'-phenylguanidines. The crude products were then converted to the desired diphenylamines by Smiles rearrangement and hydrolysis. 2-Hydroxy-4'-nitro-3'-trifluoromethyldiphenylamine (13), which shows a relative binding affinity (RBA) to the androgen receptor (AR) of 6.5% of that of testosterone, exerts a higher affinity than hydroxyflutamide (RBA = 4.5). Shift of the hydroxy-function to position 3 or 4 as well as N-methylation caused a decrease in AR-affinity. Compounds exerting AR-affinity were tested for antiandrogenic activity. Compound 13 showed the best antiandrogenic effect, though less than the well-known antiandrogen flutamide.
