393165-20-3

Basic information

• Product Name: (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride
• Synonyms: (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride
• CAS NO: 393165-20-3
• Molecular Weight: 173.574
• Mol File: 393165-20-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride(393165-20-3)
• EPA Substance Registry System: (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride(393165-20-3)

Safety Data

• Hazardous Substances Data: 393165-20-3(Hazardous Substances Data)

Usage

Description

(Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is a chemical compound characterized by a benzene ring with a fluorine substituent, a carboximidoyl chloride group, and a hydroxy functional group. It is known for its role in organic synthesis and its utility in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
(Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is used as a reagent for the production of various drugs. Its ability to form bonds with nitrogen and oxygen atoms makes it a valuable building block for complex organic molecules, which are essential in the development of new pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is used as a key component in the formation of amides and imidoyl chlorides. Its unique structure allows for the creation of a wide range of chemical compounds with diverse applications.
Used in the Synthesis of Bioactive Compounds:
(Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride is also utilized in the synthesis of bioactive and medicinally relevant compounds due to its potential to facilitate the creation of molecules with significant biological activity. This makes it a crucial component in the development of new drugs and therapies.

Upstream product

• 459-23-4 4-fluorobenzaldoxime 
• 588-95-4 syn-4-fluorobenzaldoxime 
• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 49750-46-1 p-fluorobenzonitrile oxide 
• 491875-99-1 3-(4-fluoro-phenyl)-5-methylisoxazole 
• 673451-63-3 C₁₇H₁₄FN₃O₃S 
• 238743-27-6 N-[[4,5-dihydro-3-[4-fluorophenyl]-5-isoxazolyl]methyl]acetamide 
• 159693-06-8 3-(4-fluoro-phenyl)-isoxazole-4-carboxylic acid ethyl ester 
• 954230-39-8 3-(4-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 1018297-63-6 [3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol 
• 1159600-30-2 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester 
• 1159600-32-4 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid 
• 1736-21-6 3-(4-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 1615228-56-2 N-benzyl-2-(2-(4-fluorophenyl)-2-oxoacetamido)-N-methylacetamide 
• 1431329-33-7 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinonitrile 
• 125160-90-9 3-(p-fluorophenyl)-5-(γ-hydroxypropyl)isoxazole 

Relevant articles and documents

Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters

Redox-active esters (RAEs) as alkyl radical precursors have been extensively developed for C?C bond formations. However, the analogous transformations of fluoroalkyl radicals from the corresponding acid or ester precursors remain challenging because of the high oxidation potential of the fluoroalkyl carboxylate anions. The newly developed N-hydroxybenzimidoylchloride (NHBC) ester provides a general leaving group assisted strategy to generate a portfolio of fluoroalkyl radicals, and can be successfully applied in photoinduced decarboxylative hydrofluoroalkylation and heteroarylation of unactivated olefins. In addition, DFT calculations revealed that the NHBC ester proceeds by the fluorocarbon radical pathway, whereas other well-known RAEs proceed by the nitrogen radical pathway.

Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides

(Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged s

ISOXAZOLES AND THEIR USE IN THE TREATMENT OF ISCHEMIC DISEASES

The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof. These compounds are useful for the treatment of neurological, neurodegenerative, ischemic and inflammatory disorders. Accordingly, the invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of neurological, neurodegenerative, ischemic and inflammatory disorders.