393796-18-4Relevant articles and documents
Enantioselective 1,4-addition of unmodified ketone catalyzed by a bimetallic Zn-Zn-linked-binol complex
Kumagai, Naoya,Matsunaga, Shigeki,Shibasaki, Masakatsu
, p. 4251 - 4254 (2001)
(Matrix Presented) 1,4-Addition (Michael addition) of 2-hydroxy-2′-methoxyacetophenone (2) to various αβ-unsaturated ketones was efficiently promoted by a bimetallic Zn-Zn-linked-BINOL complex 3 with good yield (up to 90%) and excellent enantiomeric excess (up to 99% ee). The resulting 2-hydroxy-1,5-diketones were successfully converted to synthetically more versatile esters and amides.