3939-12-6 Usage
Description
5-Cyano-2-fluoropyridine is a heterocyclic compound characterized by the presence of a pyridine ring with a cyano group at the 5th position and a fluorine atom at the 2nd position. It is an important raw material and intermediate used in various fields, including organic synthesis, agrochemical, pharmaceutical, and dyestuff industries.
Uses
Used in Organic Synthesis:
5-Cyano-2-fluoropyridine is used as a key intermediate for the synthesis of various organic compounds, such as pharmaceuticals, agrochemicals, and dyes. Its unique structure allows for versatile chemical reactions, making it a valuable building block in the development of new molecules with desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Cyano-2-fluoropyridine is used as a starting material for the synthesis of various drug candidates. Its presence in the molecular structure can impart specific biological activities, such as anti-inflammatory, analgesic, or antimicrobial properties, depending on the final compound's design.
Used in Agrochemical Industry:
5-Cyano-2-fluoropyridine is utilized as a precursor in the development of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, leading to improved crop yields and protection.
Used in Dye Industry:
In the dye industry, 5-Cyano-2-fluoropyridine is employed as a building block for the synthesis of various dyes with specific color properties. Its unique structure allows for the creation of dyes with improved colorfastness, brightness, and stability, making them suitable for various applications, such as textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 3939-12-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,3 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3939-12:
(6*3)+(5*9)+(4*3)+(3*9)+(2*1)+(1*2)=106
106 % 10 = 6
So 3939-12-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H3FN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H
3939-12-6Relevant articles and documents
Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination
Bland, Douglas C.,Lee, So Jeong,Morales-Colón, Mariá T.,Sanford, Melanie S.,Scott, Peter J. H.,See, Yi Yang
supporting information, p. 4493 - 4498 (2021/06/28)
Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations is the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alcohol adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alcohol substituent (R), tetramethylammonium fluoride tert-amyl alcohol (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80 °C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles is demonstrated.
PROCESS FOR FLUORINATING COMPOUNDS
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Page/Page column 29; 33; 34, (2017/02/28)
Disclosed are mild temperature (e.g., from 0 to 80°C) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F.
