394735-28-5

Basic information

• Product Name: 3-Azabicyclo[3.1.0]hexane-2-carboxaMide, N-[3-aMino-1-(cyclobutylMethyl)-2-hydroxy-3-oxopropyl]-3-[(2S)-2-[[[(1,1 -diMethylethyl)aMino]carbonyl]aMino]-3,3-diMethyl-1-oxobutyl]-6,6-diMe thyl-, (1R,2S,5S)-
• Synonyms: 3-Azabicyclo[3.1.0]hexane-2-carboxaMide, N-[3-aMino-1-(cyclobutylMethyl)-2-hydroxy-3-oxopropyl]-3-[(2S)-2-[[[(1,1 -diMethylethyl)aMino]carbonyl]aMino]-3,3-diMethyl-1-oxobutyl]-6,6-diMe thyl-, (1R,2S,5S)-;Hydro-Boceprevir;(1R,2S,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2-hydroxy-3-oxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;(1R,2S,5S)-N-(4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;(1R,2S,5S)-N-(4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• CAS NO: 394735-28-5
• Molecular Formula: C₂₇H₄₇N₅O₅
• Molecular Weight: 521.69258
• Mol File: 394735-28-5.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Azabicyclo[3.1.0]hexane-2-carboxaMide, N-[3-aMino-1-(cyclobutylMethyl)-2-hydroxy-3-oxopropyl]-3-[(2S)-2-[[[(1,1 -diMethylethyl)aMino]carbonyl]aMino]-3,3-diMethyl-1-oxobutyl]-6,6-diMe thyl-, (1R,2S,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azabicyclo[3.1.0]hexane-2-carboxaMide, N-[3-aMino-1-(cyclobutylMethyl)-2-hydroxy-3-oxopropyl]-3-[(2S)-2-[[[(1,1 -diMethylethyl)aMino]carbonyl]aMino]-3,3-diMethyl-1-oxobutyl]-6,6-diMe thyl-, (1R,2S,5S)-(394735-28-5)
• EPA Substance Registry System: 3-Azabicyclo[3.1.0]hexane-2-carboxaMide, N-[3-aMino-1-(cyclobutylMethyl)-2-hydroxy-3-oxopropyl]-3-[(2S)-2-[[[(1,1 -diMethylethyl)aMino]carbonyl]aMino]-3,3-diMethyl-1-oxobutyl]-6,6-diMe thyl-, (1R,2S,5S)-(394735-28-5)

Safety Data

• Hazardous Substances Data: 394735-28-5(Hazardous Substances Data)

Upstream product

• 1036931-36-8 3-amino-4-cyclobutyl-2-hydroxybutanamide hydrochloride 
• 1034917-71-9 C₈H₁₇N*C₁₉H₃₃N₃O₄ 
• 816430-02-1 ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate 
• 569679-06-7 3-(tert-butyl) 2-methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 
• 394735-17-2 ethyl 2-amino-3-cyclobutylpropanoate 
• 864765-28-6 3-(tert-butoxycarbonylamino)-4-cyclobutyl-2-hydroxybutanoic acid 
• 394735-21-8 methyl 3-tert-butoxycarbonylamino-4-cyclobutyl-2-hydroxybutyrate 
• 394735-18-3 tert-butyl 3-cyclobutyl-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate 
• 565456-75-9 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoic acid 
• 394735-20-7 (2-cyano-1-cyclobutylmethyl-2-hydroxyethyl)carbamic acid tert-butyl ester 
• 394735-19-4 (2-cyclobutyl-1-formylethyl)carbamic acid tert-butyl ester 
• 816444-90-3 (1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid 

Downstream Products

• 394730-60-0 boceprevir 
• 816444-90-3 (1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid 

Relevant articles and documents

Anti-hepatitis c drug Boceprevir intermediate IV and its preparation method and application (by machine translation)

The present invention relates to anti-hepatitis c drugs used in the technical field of a method for preparing Boceprevir. The invention provides compound IV (F-1) structural formula is as follows. The preparation of such compounds, the operation is simple, high yield. Using this kind of compound can be used for the synthesis of anti-hepatitis c drug Boceprevir, for the synthesis of anti-hepatitis c drug Boceprevir provides a new concept and method. And this kind of compound with ultraviolet chromophoric groups in the molecule is the original synthetic method to detect the more convenient, the benzyl hydroxyl groups on the introduction of condensation step is avoided due to the side reaction caused by the nucleophilic hydroxyl groups, compared with the prior method for synthesis of a certain advantage. (by machine translation)

Anti-hepatitis c drug Boceprevir intermediate VII and its preparation method and application

The present invention relates to the technical field of a method for preparation of an anti-HCV drug Boceprevir. The present invention provides compounds VII (C) of a formula as follows. The preparation of the compounds is simple and of high yield. The compounds can be used for synthesis of the anti-HCV drug Boceprevir. The present invention provides new implication and approach for the synthesis of the anti-HCV drug Boceprevir. Furthermore, a UV chromophore of the compounds makes the compounds more convenient to detect than compounds prepared by aconventional synthetic method, and introduction of a benzyl group to a hydroxyl group avoids side reactions during a condensation step due to the nucleophilicity of the hydroxyl group. There are certain advantages compared to an existing synthetic method.

Anti-hepatitis c drug Boceprevir intermediates II and its preparation method and application

The present invention relates to the technical field of a method for preparation of an anti-HCV drug Boceprevir. The present invention provides compounds F of a formula as follows. The preparation of the compounds is simple and of high yield. The compounds can be used for synthesis of the anti-HCV drug Boceprevir. The present invention provides new implication and approach for the synthesis of the anti-HCV drug Boceprevir. Furthermore, a UV chromophore of the compounds makes the compounds more convenient to detect than compounds prepared by a conventional synthetic method, and introduction of a benzyl group to a hydroxyl group avoids side reactions during a condensation step due to the nucleophilicity of the hydroxyl group. There are certain advantages compared to an existing synthesis synthetic method.