39538-31-3

Basic information

• Product Name: Z-GLU(OME)-OSU
• Synonyms: Z-GLUTAMIC ACID(OME)-OSU;Z-GLU(OME)-OSU;Z-L-GLUTAMIC ACID GAMMA-METHYL ALPHA-HYDROXYSUCCINIMIDE DIESTER;Z-L-GLUTAMIC ACID GAMMA-METHYL ESTER ALPHA-N-HYDROXYSUCCINIMIDE ESTER;Z-L-GLUTAMIC ACID Y-METHYL A-HYDROXYSUCCINIMID-DIESTER;(S)-5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxo-4-[[(benzyloxy)carbonyl]amino]valeric acid methyl ester;Z-L-Glu(OMe)-OSu;Z-L-glutamic acid γ-methyl ester α-N-hydroxysuccinimide ester99%
• CAS NO: 39538-31-3
• Molecular Formula: C₁₈H₂₀N₂O₈
• Molecular Weight: 392.36
• Mol File: 39538-31-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-GLU(OME)-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: Z-GLU(OME)-OSU(39538-31-3)
• EPA Substance Registry System: Z-GLU(OME)-OSU(39538-31-3)

Safety Data

• Hazardous Substances Data: 39538-31-3(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 4652-65-7 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester 
• 1499-55-4 L-glutamic acid 5-methyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 222027-29-4 (S)-2,2-Dimethyl-4-(4-oxo-3-phenoxy-cyclohex-2-enylmethyl)-oxazolidine-3-carboxylic acid benzyl ester 
• 222027-12-5 (4S)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-(methoxycarbonylethyl)oxazolidine 
• 222027-19-2 (4S)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-(3-oxo-propyl)oxazolidine 
• 223472-23-9 methyl (4S)-4-{[(benzyloxy)carbonyl]amino}-5-(ethoxymethoxy)pentanoate 
• 861819-88-7 methyl (4S)-5-ethoxymethoxy-4-[(4-methylbenzoyl)amino]pentanoate 
• 861819-89-8 (4S)-5-ethoxymethoxy-4-[(4-methylbenzoyl)amino]pentanoic acid 
• 119109-58-9 4-(S)-[4-(N-benzyloxycarbonylamino)-5-hydroxy]pentanoic acid methyl ester 

Relevant articles and documents

Novel matrix metalloproteinase inhibitors: Generation of lead compounds by the in silico fragment-based approach

Generation of structurally new matrix metalloproteinase inhibitors was successfully carried out using an in silico technique. In order to identify the small fragment interacting with residues in the S1′ pocket of MMP-1 through hydrogen bonds, we performed in silico screening using the LUDI program. As a result, acetyl-l-alanyl-(N-methyl)amide (Ac-l-Ala-NHMe) was selected to link with another fragment, hydroxamic acid that interacted with catalytic zinc. By this approach, the l-glutamic acid derivative 2b was discovered to be a new type of matrix metalloproteinase inhibitor. Further transformation to reduce its peptidic nature and improve activity yielded nonpeptidic lead compounds as inhibitors of MMP-1, -2, -3, and -9.