39616-99-4

Basic information

• Product Name: 1-(4-fluoro-2-nitrophenyl)propan-2-one
• Synonyms: 1-(4-fluoro-2-nitrophenyl)propan-2-one
• CAS NO: 39616-99-4
• Molecular Weight: 197.166
• Mol File: 39616-99-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(4-fluoro-2-nitrophenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluoro-2-nitrophenyl)propan-2-one(39616-99-4)
• EPA Substance Registry System: 1-(4-fluoro-2-nitrophenyl)propan-2-one(39616-99-4)

Safety Data

• Hazardous Substances Data: 39616-99-4(Hazardous Substances Data)

Usage

Type of compound

Ketone

Functional groups

4-fluoro-2-nitrophenyl, propan-2-one

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Structural significance

Unique structure and reactivity in organic synthesis

Applications

Medicinal chemistry, drug discovery

Potential

Development of new therapeutic agents

Chemical properties

Nitro and fluoro substitutions

Biological properties

Valuable tool in creating novel compounds with pharmaceutical utility

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 123-54-6 acetylacetone 
• 606092-02-8 3‐(4‐fluoro‐2‐nitrophenyl)‐4‐hydroxypent‐3‐en‐2‐one 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 1143455-27-9 (E)-3-(4-fluoro-2-nitrophenyl)-4-hydroxy-4-(methyloxy)-3-buten-2-one 
• 606092-03-9 2-[4-fluoro-2-nitrophenyl]-3-hydroxy-2-butenoic acid methyl ester (2-[4-fluoro-2-nitrophenyl]-3-oxobutanoic acid methyl ester) 

Downstream Products

• 40311-13-5 6-fluoro-2-methyl-1H-indole 

Relevant articles and documents

Method for preparing indole and derivatives thereof

The invention discloses a method for preparing indole and derivatives of indole. The method for preparing indole and the derivatives of indole is characterized by comprising the following two steps that (1) a catalyst, a ligand and alkali are added in a reaction tube, under the protection of nitrogen, beta-hydroxy ketone or ester is reacted with a mixed solution of o-nitro aryl halides for 3 to 8h in an oil bath pan at the temperature of 90 to 120 DEG C, and then cooled to room temperature after reaction, and extracted, washed, dried and subjected to chromatography to obtain a product of o-nitro alpha-aryl ketone or ester; (2) o-nitro alpha-aryl ketone or ester obtained in the step (1), a reducing agent system and a solvent are added to the reaction tube, and reacted for 3 to 8h at the temperature of 60 to 100 DEG C, and then extracted, washed, dried and subjected to chromatography after being reacted to obtain a target product of indole and the derivatives of indole. Reaction raw materials, the catalyst, the ligand, the alkali and the solvent used in the invention are all industrial commodities, and simple and readily available, wide in sources, cheap in price, and further very stable in performances, and with no need for special storage conditions; in addition, the method for preparing indole and the derivatives of indole disclosed by the invention has the characteristics of low cost, high yield, simple process, less pollution and the like.

PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS

The present invention relates to a compound of the formula (I), or a pharmaceutically acceptable salt thereof, wherein R1-R8 and X, m, and n are defined. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.