3965-59-1

Basic information

• Product Name: 1-Hexanol, 2,4-dimethyl-
• CAS NO: 3965-59-1
• Molecular Formula: C8H18O
• Molecular Weight: 130.23
• Mol File: 3965-59-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Hexanol, 2,4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hexanol, 2,4-dimethyl-(3965-59-1)
• EPA Substance Registry System: 1-Hexanol, 2,4-dimethyl-(3965-59-1)

Safety Data

• Hazardous Substances Data: 3965-59-1(Hazardous Substances Data)

Usage

Physical State

Colorless liquid

Odor

Mild, sweet, floral

Uses

a. Flavoring agent in food
b. Solvent in organic synthesis
c. Component in fragrances and perfumes
d. Manufacturing of plasticizers
e. Manufacturing of antifoaming agents
f. Other industrial applications

Solubility

Slightly soluble in water

Toxicity

Relatively non-toxic

Health Effects

Can cause irritation to eyes, skin, and respiratory system upon exposure

Synthesis Method

Acid-catalyzed hydration of 2,4-dimethyl-1-pentene

Upstream product

• 1501971-59-0 (2R,3S,4R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2,4-dimethyl-1-oxohexan-3-yl-4-methylbenzenesulfonate 

Downstream Products

• 103034-77-1 phthalic acid bis-(2,4-dimethyl-hexyl ester) 
• 52718-79-3 n-Heptaldehyd-tosylhydrazon 
• 1309567-72-3 4-hydroxy-5-(4-hydroxyphenyl)-3-((2E,4E,6R,8R)-4,6,8-trimethyldeca-2,4-dienoyl)pyridin-2(1H)-one 
• 1309567-84-7 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-3-((2E,4E,6E,8R,10R)-6,8,10-trimethyldodeca-2,4,6-trienoyl)pyridin-2(1H)-one 

Relevant articles and documents

Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities

A collective synthesis of 4-hydroxy-2-pyridone alkaloids - specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C - has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μM. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.