39718-97-3

Basic information

• Product Name: methyl 2-(4-aminophenyl)propionate
• Synonyms: methyl 2-(4-aminophenyl)propionate;4-Amino-α-methylbenzeneacetic acid methyl ester;α-Methyl-4-aminobenzeneacetic acid methyl ester;Methyl 2-(4-aminophenyl)propanoate
• CAS NO: 39718-97-3
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• EINECS: 254-605-1
• Mol File: 39718-97-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 287.7°Cat760mmHg
• Flash Point: 145.6°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.00244mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 2-(4-aminophenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-aminophenyl)propionate(39718-97-3)
• EPA Substance Registry System: methyl 2-(4-aminophenyl)propionate(39718-97-3)

Safety Data

• Hazardous Substances Data: 39718-97-3(Hazardous Substances Data)

Usage

General Description

Methyl 2-(4-aminophenyl)propionate is a chemical compound with the molecular formula C11H15NO2. It is an ester consisting of a methyl group attached to the carbon of a 2-(4-aminophenyl)propionate. methyl 2-(4-aminophenyl)propionate is commonly used in the pharmaceutical and medical industry as a precursor in the synthesis of various drugs, especially analgesics and anti-inflammatory medications. It is also used in research and development labs as a building block in the creation of new therapeutic compounds. Methyl 2-(4-aminophenyl)propionate is considered an important intermediate in organic synthesis due to its versatile nature and wide range of applications.

InChI:InChI=1/C10H13NO2/c1-7(10(12)13-2)8-3-5-9(11)6-4-8/h3-7H,11H2,1-2H3

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 2945-08-6 methyl (4-nitrophenyl)acetate 
• 67-56-1 methanol 
• 19910-33-9 2-(4-nitrophenyl)propanoic acid 
• 100-00-5 4-chlorobenzonitrile 
• 61881-49-0 Diethyl 2-methyl-2-(4-nitrophenyl)malonate 
• 34880-70-1 [1-methoxyprop-1-enyloxy]trimethylsilane 
• 106-47-8 4-chloro-aniline 
• 50415-69-5 methyl 2-(4-nitrobenzene)propionate 
• 28042-27-5 α-Methylene-4-nitrobenzeneacetic acid methyl ester 

Downstream Products

• 874962-83-1 1-[4-(2-methoxy-1-methyl-2-oxoethyl)phenyl]-5-oxoproline 
• 852068-62-3 methyl 2-[4-(2,4-dioxoimidazolidin-1-yl)phenyl]propanoate 
• 1230992-37-6 Ethyl 2-[4-(2-hydroxyethylamino)phenyl]propionate 
• 76302-29-9 2-[4-(2'-pyridylamino)phenyl]propionic acid 
• 890839-11-9 methyl 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan -2-yl)phenyl]propionate 
• 852068-64-5 2-(4-isocyanato-phenyl)-propionic acid methyl ester 
• 852068-70-3 2-[4-(3-chloro-propane-1-sulfonylamino)-phenyl]-propionic acid methyl ester 
• 83528-23-8 2-[4-(4-Methyl-pyridin-2-ylamino)-phenyl]-propionic acid methyl ester 
• 83528-25-0 2-[4-(6-Methyl-pyridin-2-ylamino)-phenyl]-propionic acid methyl ester 
• 83528-18-1 2-[4-(Pyridin-2-ylamino)-phenyl]-propionic acid methyl ester 
• 65784-33-0 methyl 2-(4-hydroxyphenyl)propanoate 
• 109227-01-2 methyl 4-<2,2-dimethyl-6-nitro-2H-1,4-benzoxazin-3-yl>amino-α-methylphenylacetate 
• 109227-02-3 methyl 4-<7-nitro-2H-1,4-benzoxazin-3-yl>amino-α-methylphenylacetate 
• 109226-99-5 methyl 4-<6-nitro-2H-1,4-benzoxazin-3-yl>amino-α-methylphenylacetate 

Relevant articles and documents

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

Activation of the nuclear farnesoid X receptor (FXR) which acts as cellular bile acid sensor has been validated as therapeutic strategy to counter liver disorders such as non-alcoholic steatohepatitis by the clinical efficacy of obeticholic acid. FXR antagonism, in contrast, is less well studied and potent small molecule FXR antagonists are rare. Here we report the systematic optimization of a novel class of FXR antagonists towards low nanomolar potency. The most optimized compound antagonizes baseline and agonist induced FXR activity in a full length FXR reporter gene assay and represses intrinsic expression of FXR regulated genes in hepatoma cells. With this activity and a favorable toxicity-, stability- and selectivity-profile it appears suitable to further study FXR antagonism in vitro and in vivo.

Photochemical intramolecular amination for the synthesis of heterocycles

Polycyclic heterocycles can be formed in good to excellent yields via photochemical conversion of the corresponding substituted aryl azides under irradiation with purple LEDs in a continuous flow reactor. The experimental set-up is tolerant to UV-sensitive functional groups while affording diverse carbazoles, as well as an indole and pyrrole framework, in short reaction times. The photochemical method is presumed to progress through a mechanism differing from the other methods of azide activation involving transition metal catalysis.

Transition metal free intramolecular selective oxidative C(sp3)-N coupling: Synthesis of N-aryl-isoindolinones from 2-alkylbenzamides

A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp3)-H and N-H bonds utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110-140 °C.