39742-51-3

Basic information

• Product Name: 8-[2-(4-Methoxy-phenyl)-ethyl]-1,4-dioxa-8-aza-spiro[4.5]decane
• Synonyms: 8-[2-(4-Methoxy-phenyl)-ethyl]-1,4-dioxa-8-aza-spiro[4.5]decane
• CAS NO: 39742-51-3
• Molecular Weight: 277.364
• Mol File: 39742-51-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-[2-(4-Methoxy-phenyl)-ethyl]-1,4-dioxa-8-aza-spiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[2-(4-Methoxy-phenyl)-ethyl]-1,4-dioxa-8-aza-spiro[4.5]decane(39742-51-3)
• EPA Substance Registry System: 8-[2-(4-Methoxy-phenyl)-ethyl]-1,4-dioxa-8-aza-spiro[4.5]decane(39742-51-3)

Safety Data

• Hazardous Substances Data: 39742-51-3(Hazardous Substances Data)

Upstream product

• 177-11-7 4,4-ethylenedioxy-piperidine 

Downstream Products

• 73735-61-2 (1-benzyl-1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)-piperidin-4-yl)amine 
• 124794-72-5 1-(2-aminophenyl)-3-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)thiourea 
• 104472-63-1 (1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine 
• 85098-70-0 4-amino-1-(2-(4-methoxyphenyl)ethyl)piperidine 
• 39742-63-7 1-[2-(4-methoxyphenyl)ethyl]-4-piperidone 

Relevant articles and documents

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vitro and in vivo antihistaminic activity are described. Cyclodesulfurization of (2-aminophenyl) thioureas with mercury(II) oxide resulted in 2-aminobenzimidazole intermediates, which were monoalkylated on the endo-nitrogen atom. After deprotection of the piperideine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions. The in vivo antihistaminic activity was evaluated by the compound 48/80 induced lethality test in rats and histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration. The duration of action, for a selected number of compounds, was studied in the guinea pig. The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species.