398130-08-0

Basic information

• Product Name: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(methylthio)-, 5-oxime
• CAS NO: 398130-08-0
• Molecular Formula: C12H12N2O3S
• Molecular Weight: 264.305
• Mol File: 398130-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(methylthio)-, 5-oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(methylthio)-, 5-oxime(398130-08-0)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(methylthio)-, 5-oxime(398130-08-0)

Safety Data

• Hazardous Substances Data: 398130-08-0(Hazardous Substances Data)

Upstream product

• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 398130-27-3 3-(4-methoxy-phenyl)-1-methyl-4-methylsulfanyl-pyrrole-2,5-dione 
• 32857-93-5 (3RS)-3-(4-methoxyphenyl)-1-methylpyrrolidine-2,5-dione 
• 398130-17-1 3-(4-methoxyphenyl)-4-(methylthio)-1H-pyrrole-2,5-dione 
• 27950-85-2 3-(4-methoxyphenyl)-pyrrolidine-2,5-dione 

Relevant articles and documents

Synthesis of 3-methylthio-4-aryl-3-pyrroline-2,5-diones and 3-arylpyrolidine-2,5-diones by reaction of nitroketene dithioacetal with arylacetonitriles

The reaction of nitroketene dithioacetal (1a), i.e., 2,2-bis(methylthio)-1-nitroethylene, with arylacetonitriles (2a-I) in the presence of the base like sodium hydroxide gave 4-nitrobut-2-enenitriles (3a-I) which were convened into 5-hydroxyimino-4-methylthio-3-phenyl-3-pyrrolin-2-ones (4a-i) under refluxing in methanol. Title compounds (5a-i) were readily obtained by the treatment of 4a-i with hydrochloric acid and were finally led to N-methylated products (6a-I) with methyl iodide. The reduction of maleimides (4 - 6) with zinc dust in acetic acid afforded the corresponding 3-arylpyrrolidine-2,5-diones (7a-i) that can be convened to pharmacologycally active compounds like mesembrines.