39830-66-5 Usage
Description
Methyl indole-4-carboxylate is an off-white to green crystalline powder with distinct IR and UV spectra, which is utilized as a versatile reactant in the synthesis of various compounds for pharmaceutical and chemical applications.
Uses
1. Used in Pharmaceutical Industry:
Methyl indole-4-carboxylate is used as a reactant for the preparation of tryptophan dioxygenase inhibitors, specifically pyridyl-ethenyl-indoles, which serve as potential anticancer immunomodulators.
2. Used in Cancer Treatment:
Methyl indole-4-carboxylate is used as a reactant for the preparation of cytotoxic agents against multidrug-resistant cancer cells, aiding in the development of novel therapeutic strategies to combat drug resistance in cancer treatment.
3. Used in Enzyme Inhibition:
Methyl indole-4-carboxylate is used as a reactant for the preparation of inhibitors for β-tryptase, an enzyme involved in various physiological processes and diseases.
4. Used in Allergy and Inflammation Treatment:
Methyl indole-4-carboxylate is used as a reactant for the preparation of histamine H3 antagonists, which have potential applications in the treatment of allergies and inflammation.
5. Used in Neurodegenerative Disease Research:
Methyl indole-4-carboxylate is used as a reactant for the preparation of JNK3 MAP kinase inhibitors, which may have implications in the study and treatment of neurodegenerative diseases.
6. Used in Nucleoside Synthesis:
Methyl indole-4-carboxylate is used as a reactant for the preparation of nucleosides, which are essential components of nucleic acids and have applications in genetic research and the development of antiviral drugs.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 26, p. 1405, 1989 DOI: 10.1002/jhet.5570260533Chemical and Pharmaceutical Bulletin, 29, p. 249, 1981 DOI: 10.1248/cpb.29.249
Check Digit Verification of cas no
The CAS Registry Mumber 39830-66-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,8,3 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 39830-66:
(7*3)+(6*9)+(5*8)+(4*3)+(3*0)+(2*6)+(1*6)=145
145 % 10 = 5
So 39830-66-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2/c1-13-10(12)8-3-2-4-9-7(8)5-6-11-9/h2-6,11H,1H3
39830-66-5Relevant articles and documents
Synthesis of diverse indole libraries on polystyrene resin - Scope and limitations of an organometallic reaction on solid supports
Knepper, Kerstin,Vanderheiden, Sylvia,Braese, Stefan
experimental part, p. 1191 - 1199 (2012/09/07)
The synthesis of diverse substituted indole structures on solid supports is described. The immobilization of nitrobenzoic acid onto Merrifield resin and the subsequent treatment with alkenyl Grignard reagents delivered indole carboxylates bound to solid s
