39880-77-8 Usage
Description
2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI), also known as N-Methylthiophene-2-carboxamide, is an organic compound with the molecular formula C6H7NS. It is characterized by the presence of a thiophene ring, an amide group, and a methyl group. 2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI) is known for its potential applications in various industries, particularly as an impurity in pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
2-Thiophenecarboxamide,N-methyl-(6CI,7CI,9CI) is used as an impurity in the production of Tenoxicam (T019500), a nonsteroidal anti-inflammatory agent. It plays a role in the synthesis process of the drug, contributing to its overall effectiveness in reducing inflammation and pain. The presence of this compound in Tenoxicam is carefully monitored and controlled to ensure the safety and efficacy of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 39880-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,8,8 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 39880-77:
(7*3)+(6*9)+(5*8)+(4*8)+(3*0)+(2*7)+(1*7)=168
168 % 10 = 8
So 39880-77-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H7NOS/c1-7-6(8)5-3-2-4-9-5/h2-4H,1H3,(H,7,8)
39880-77-8Relevant articles and documents
Atom-Economical and Tandem Conversion of Nitriles to N-Methylated Amides Using Methanol and Water
Paul, Bhaskar,Maji, Milan,Kundu, Sabuj
, p. 10469 - 10476 (2019/11/05)
A cobalt complex catalyzed tandem conversion of nitrile to N-methylated amide is described using a methanol and water mixture. Using this protocol, several nitriles were directly and efficiently converted to the desired N-methylated amides. Kinetic experiments using H2O18 and CD3OD suggested that water and methanol were the source of the oxygen atom and methyl group, respectively, in the final N-methylated amides. Importantly, the participation of active Co(I)-H species in this transformation was realized from the control experiment. The kinetic isotope effect (KIE) study suggested that the activation of the C-H bond of methanol was a kinetically important step. The Hammett plot confirmed that the reaction was faster with the electron deficient nitriles. In addition, the plausible pathway for the formation of N-methylated amides from the nitriles was supported by the computational study.