399-66-6

Basic information

• Product Name: (1,2,4)Triazolo(1,5-a)pyrazine
• Synonyms: (1,2,4)Triazolo(1,5-a)pyrazine
• CAS NO: 399-66-6
• Molecular Formula: C₅H₄N₄
• Molecular Weight: 120.11
• Mol File: 399-66-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 125-126 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.48g/cm³
• Refractive Index: 1.772
• PKA: 0.08±0.30(Predicted)
• CAS DataBase Reference: (1,2,4)Triazolo(1,5-a)pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2,4)Triazolo(1,5-a)pyrazine(399-66-6)
• EPA Substance Registry System: (1,2,4)Triazolo(1,5-a)pyrazine(399-66-6)

Safety Data

• Hazardous Substances Data: 399-66-6(Hazardous Substances Data)

Usage

General Description

(1,2,4)Triazolo(1,5-a)pyrazine is a heterocyclic compound containing a triazole ring fused to a pyrazine ring. It is a colourless solid and has the molecular formula C5H4N4. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and functional materials. It also has potential applications in materials science and organic electronics. Its unique structure and properties make it valuable in various research and industrial settings, and it is essential for the development of new compounds and materials.

InChI:InChI=1/C5H4N4/c1-2-9-5(3-6-1)7-4-8-9/h1-4H

Upstream product

• 1575612-94-0 (E)-N'-hydroxy-N-(pyrazin-2-yl)formimidamide 
• 51519-20-1 N'-hydroxy-N-(pyrazin-2-yl)formimidamide 
• 51519-20-1 C₅H₆N₄O 
• 51519-09-6 N,N-dimethyl-N'-(pyrazin-2-yl)formamidine 
• 51519-20-1 N-hydroxy-N'-pyrazin-2-ylimidoformamide 

Downstream Products

• 55366-16-0 8-hydrazino-[1,2,4]triazolo[1,5-a]pyrazine 
• 74803-32-0 8-chloro-1,2,4-triazolo<1,5-a>pyrazine 
• 74803-31-9 8-anilino-1,2,4-triazolo<1,5-a>pyrazine 
• 233278-56-3 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine 
• 1575608-04-6 (2R,3R)-2-(2,4-difluorophenyl)-3-(5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1613021-91-2 (S)-N-(1-([1,2,4]-triazolo[1,5-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamide 

Relevant articles and documents

T3P-Mediated N-N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5- a]pyridines

Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]triazolo[1,5-a]pyridines from the corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering the triazolopyridines in good to excellent yields and purities.

CXCR7 ANTAGONISTS

Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.