399-69-9

Basic information

• Product Name: 2,5-BIS(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE
• Synonyms: ZERENEX E/6026518;2,5-BIS(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE;1H-BENZIMIDAZOLE, 2,5-BIS(TRIFLUOROMETHYL)-;2,6-Bis(trifluoromethyl)-1H-benzimidazole;2,5-Bis-trifluoromethyl-1H-benzoimidazole
• CAS NO: 399-69-9
• Molecular Formula: C₉H₄F₆N₂
• Molecular Weight: 254.13
• Mol File: 399-69-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 270.1°Cat760mmHg
• Flash Point: 117.1°C
• Appearance: /
• Density: 1.567g/cm³
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: 2,5-BIS(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-BIS(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE(399-69-9)
• EPA Substance Registry System: 2,5-BIS(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE(399-69-9)

Safety Data

• Hazardous Substances Data: 399-69-9(Hazardous Substances Data)

Usage

General Description

2,5-Bis(trifluoromethyl)-1H-benzimidazole is a chemical compound with the molecular formula C9H4F6N2. It is a white solid that is insoluble in water but soluble in organic solvents. 2,5-BIS(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE is often used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and electronic materials. It is also known for its high thermal and chemical stability, making it an important intermediate for the production of high-performance materials. Additionally, 2,5-Bis(trifluoromethyl)-1H-benzimidazole has been studied for its potential applications in the field of medicinal chemistry, including as an antimicrobial and antiviral agent.

InChI:InChI=1/C9H4F6N2/c10-8(11,12)4-1-2-5-6(3-4)17-7(16-5)9(13,14)15/h1-3H,(H,16,17)

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Relevant articles and documents

Fe(OTf)3-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles from o-arylenediamines and hexafluoroacetylacetone

An iron-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles through condensation of o-arylenediamines and hexafluoroacetylacetone followed by intramolecular addition and C–C bond cleavage in one-pot has been developed. A series of title compounds were obtained with up to 99% yield. This method is quite practical and suitable for scalable preparation due to simple experimental procedure and readily available reagents.

An efficient method to access 2-fluoroalkylbenzimidazoles by PIDA oxidation of amidines

A mild and practical strategy for the synthesis of 2-bromodifluoromethyl (or trifluoromethyl)-1H-benzimidazoles via PIDA-mediated oxidative intramolecular cyclization of the fluorinated amidines is described. The approach has the advantages of superior yi

Rapid one-pot preparation of 2-substituted benzimidazoles from 2-nitroanilines using microwave conditions

A high yielding one-pot procedure for the generation of 2-substituted benzimidazoles directly from 2-nitroanilines by in situ reduction and cyclization using a microwave procedure is described.