399-94-0

Basic information

• Product Name: 1-Bromo-2,5-difluorobenzene
• Synonyms: 1,4-Difluoro-2-bromobenzene;2-BROMO-1,4-DIFLUOROBENZENE;2,5-DIFLUOROBROMOBENZENE;1-BROMO-2,5-DIFLUOROBENZENE;1-Bromo-2,5-difluorobenzene 98%;1-Bromo-2,5-difluorobenzene98%;1-BROMO-2,5-DIFLUOROBENZENE 99.5%;1-Bromo-2,5-difluoro
• CAS NO: 399-94-0
• Molecular Formula: C₆H₃BrF₂
• Molecular Weight: 192.99
• EINECS: 206-920-0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;Miscellaneous;Bromine Compounds;Fluorine Compounds;Fluorobenzene Series;Aryl;C6;Halogenated Hydrocarbons;alkyl bromide| alkyl Fluorine
• Mol File: 399-94-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: −31 °C(lit.)
• Boiling Point: 58-59 °C20 mm Hg(lit.)
• Flash Point: 149 °F
• Appearance: Clear colourless liquid
• Density: 1.708 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000165mmHg at 25°C
• Refractive Index: n20/D 1.508(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble
• BRN: 1680893
• CAS DataBase Reference: 1-Bromo-2,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2,5-difluorobenzene(399-94-0)
• EPA Substance Registry System: 1-Bromo-2,5-difluorobenzene(399-94-0)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-2637/39-37/39
• RIDADR: UN 2922
• WGK Germany: 3
• HazardClass: IRRITANT, FLAMMABLE
• Hazardous Substances Data: 399-94-0(Hazardous Substances Data)

Usage

Description

1-Bromo-2,5-difluorobenzene is an organic compound with the molecular formula C6H2BrF2. It is a clear, colorless liquid that is derived from the lithiation of 2-bromo-1,4-difluorobenzene in the presence of lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane, and butyllithium in THF-hexane. 1-Bromo-2,5-difluorobenzene is known for its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
1-Bromo-2,5-difluorobenzene is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic applications.
Used in Chemical Synthesis:
1-Bromo-2,5-difluorobenzene is used as a key building block in the preparation of various organic compounds, including 1,4-difluoroanthraquinone, which is a precursor to ametantrone. 1-Bromo-2,5-difluorobenzene serves as an essential component in the development of new chemical products and materials.
Used in Material Science:
Due to its unique chemical properties, 1-Bromo-2,5-difluorobenzene can be utilized in the development of new materials with specific characteristics, such as improved thermal stability, chemical resistance, or optical properties. These materials can find applications in various industries, including electronics, automotive, and aerospace.

InChI:InChI=1/C10H10O2/c11-10(12)9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6H2,(H,11,12)/t8-,9+/m0/s1

Upstream product

• 108-86-1 bromobenzene 
• 540-36-3 para-difluorobenzene 

Downstream Products

• 167415-27-2 1-bromo-2,5-difluoro-4-nitrobenzene 
• 307306-06-5 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-β-D-ribofuranosyl]]benzene 
• 307306-05-4 2,5-difluoro-1-[1-[2-deoxy-3,5-di-O-(p-chlorobenzoyl)-α-D-ribofuranosyl]]benzene 
• 58653-71-7 3-Fluorobenzonorbornadien 
• 899819-34-2 (2,5-difluorophenyl)magnesium bromide 
• 678982-63-3 (RS)-tert-butyl 4-[(2,5-difluorophenyl)-hydroxymethyl]-piperidine-1-carboxylate 
• 179737-33-8 2,3-dibromo-1,4-difluorobenzene 
• 1443538-33-7 tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate 
• 1216260-42-2 4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one 
• 112898-33-6 3-(2,5-difluorophenyl)acrylic acid 
• 123942-11-0 4'-bromo-2 ',5'-difluoroacetophenone 
• 28736-42-7 1,4-difluoroanthracene-9,10-dione 
• 2991-28-8 2,5-difluorobenzoic acid 
• 124244-65-1 2-bromo-3,6-difluorobenzoic acid 

Relevant articles and documents

A 2, 5 - difluoro -4 - nitro benzoic acid (by machine translation)

The invention discloses a 2, 5 - difluoro - 4 - nitro-benzoic acid industrial preparation method. The 2, 5 - difluoro - 4 - nitro-benzoic acid industrial preparation method, the initial raw materials to the difluoro, through the bromo, nitration, carbonitriding, the hydrolysis of the four-step reaction synthesis of 2, 5 - difluoro - 4 - nitro-benzoic acid. The got in the course of 2, 5 - difluoro - 4 - nitrobenzoic acid as white powdery solid, purity 98.5%, each step the raw material conversion rate respectively reaches 100%, the total yield of the whole process 44.6%. (by machine translation)

Bromination of aromatic compounds using an Fe2O 3/zeolite catalyst

The catalytic bromination of non-activated aromatic compounds has been achieved using an Fe2O3/zeolite catalyst system. FeBr 3 was identified as the catalytic species, formed in situ from HBr and Fe2O3. The catalyst was easy-to-handle and cost effective and could also be recycled. The reaction system was also amenable to the one-pot sequential bromination/C-C bond formation of benzene.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.