39941-51-0

Basic information

• Product Name: uttronin A
• Synonyms: uttronin A;(25R)-3β-[[4-O-[2-O-(β-D-Glucopyranosyl)-3-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranosyl]oxy]-5α-spirostane;(25R)-3β-[4-O-(2-O-β-D-Glucopyranosyl-3-O-β-D-xylopyranosyl-β-D-glucopyranosyl)-β-D-galactopyranosyloxy]-5α-spirostane;[(25R)-5α-Spirostan-3β-yl]4-O-(2-O-β-D-glucopyranosyl-3-O-β-D-xylopyranosyl-β-D-glucopyranosyl)-β-D-galactopyranoside;[(25R)-5α-Spirostan-3β-yl]4-O-[2-O-(β-D-glucopyranosyl)-3-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranoside;beta-Lycotetraosyltigogenin;Degalactotigonin;Dihydroaspidistrin
• CAS NO: 39941-51-0
• Molecular Formula: C₅₀H₈₂O₂₂
• Molecular Weight: 1035.17288
• Mol File: 39941-51-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 284-286℃
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.49
• PKA: 12.77±0.70(Predicted)
• CAS DataBase Reference: uttronin A(CAS DataBase Reference)
• NIST Chemistry Reference: uttronin A(39941-51-0)
• EPA Substance Registry System: uttronin A(39941-51-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 39941-51-0(Hazardous Substances Data)

Usage

General Description

Uttronin A is a natural product isolated from the marine-derived fungus. It is a unique polyketide with a molecular formula of C29H21O7. uttronin A has shown potential anti-cancer properties, specifically inhibiting the proliferation of human cancer cells in vitro. It has also been found to have cytotoxic effects on a range of cancer cell lines, particularly those associated with lung and colon cancers. Uttronin A acts by disrupting microtubule dynamics in cancer cells, leading to cell cycle arrest and ultimately inducing apoptosis. Its promising anti-cancer activities make it a potential candidate for further development as a therapeutic agent for cancer treatment.

Upstream product

• 88048-09-3 C₅₆H₉₄O₂₈ 

Downstream Products

• 77-60-1 sarsasapogenin 

Relevant articles and documents

Further Studies on Steroidal Glycosides from Bulbs, Roots and Leaves of Allium sativum L.

A new furostanol glycoside (2), named sativoside-B1, was isolated from garlic, bulbs of Allium sativum L., along with proto-desgalactotigonin (3).The structure of 2 was established to be (25R)-26-O-β-D-glucopyranosyl-22-hydroxy-5α-furostane-3β,6β,26-triol 3-O-β-D-glucopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-3)-O-β-D-glucopyranosyl-(1->4)-O-β-D-galactopyranoside.From roots of this plant, two new steroidal glycosides, named sativoside-R1 (16) and sativoside-R2 (15) were isolated and their structures were determined to be (25R)-26-O-β-D-glucopyranosyl-22-hydroxy-5α-furostane-3β,26-diol 3-O-β-D-glucopyranosyl-(1->3)-O-β-D-glucopyranosyl-(1->2)-O-3)>-O-β-D-glucopyranosyl-(1->4)-O-β-D-galactopyranosyde (16) and its corresponding spirostanol glycoside (15).Besides these glycosides, three known glycosides, 3, desgalactotigonin (13) and F-gitonin (14) were isolated and identified.In a glycoside fraction of the leaves of A. sativum, steroidal glycosides were not detected by thin layer chromatography analysis.