39942-41-1 Usage
Description
4-Hydroxylidocaine is a metabolite of Lidocaine, a widely used local anesthetic and antiarrhythmic drug. It is formed during the metabolism of Lidocaine in the liver and plays a role in the drug's therapeutic effects and potential side effects.
Used in Pharmaceutical Industry:
4-Hydroxylidocaine is used as a metabolite of Lidocaine for its local anesthetic and antiarrhythmic properties. It is involved in the therapeutic effects of Lidocaine, which is commonly used to numb tissues during medical procedures and to treat abnormal heart rhythms.
Used in Research and Development:
4-Hydroxylidocaine is used as a research compound to study the metabolism and pharmacokinetics of Lidocaine. It helps researchers understand the drug's mechanism of action, efficacy, and potential side effects, which can inform the development of new drugs and treatment strategies.
Used in Toxicology Studies:
4-Hydroxylidocaine is used as a biomarker in toxicology studies to assess the safety and potential side effects of Lidocaine. It can help identify individuals who may be at risk for adverse reactions to the drug and inform appropriate dosing and monitoring strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 39942-41-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,9,4 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 39942-41:
(7*3)+(6*9)+(5*9)+(4*4)+(3*2)+(2*4)+(1*1)=151
151 % 10 = 1
So 39942-41-1 is a valid CAS Registry Number.
39942-41-1Relevant articles and documents
Mechanism of aromatic hydroxylation of lidocaine at a Pt electrode under acidic conditions
Gul, Turan,Bischoff, Rainer,Permentier, Hjalmar P.
, p. 636 - 641 (2016/12/27)
Aromatic hydroxylation reactions, which are mainly catalyzed by cytochrome P450 (CYP) enzymes in vivo, are some of the most important reactions of Phase I metabolism, because insertion of a hydroxyl group into a lipophilic drug compound increases its hydrophilicity and prepares it for subsequent Phase II metabolic conjugation reactions as a prerequisite to excretion. Aromatic hydroxylation metabolites of pharmaceuticals may be obtained through various synthetic and enzymatic methods Electrochemical oxidation is an alternative with advantages in terms of mild reaction conditions and less hazardous chemicals. In the present study, we report that aromatic hydroxylation metabolites of lidocaine can be readily obtained electrochemically under aqueous acidic conditions at platinum electrodes. Our results show that the dominant N-dealkylation reaction can be suppressed by decreasing the solution pH below 0.5 resulting in selective 3-hydroxylidocaine, which is an in vivo metabolite of lidocaine. Experiments in 18O labelled water indicated that water is the primary source of oxygen, while dissolved molecular oxygen contributes to a minor extent to the hydroxylation reaction.