39976-03-9Relevant articles and documents
Preparation method of hydroxyamide
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Paragraph 0036-0039, (2020/02/10)
The invention discloses a preparation method of a hydroxyamide shown as formula (I). The hydroxyamide is prepared through homogeneous catalytic hydrogenation reaction of a cyclic imide represented byformula (II), wherein R1, R2 and R3 are respectively and
NOVEL ULK1 INHIBITORS AND METHODS USING SAME
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Page/Page column 243; 244, (2016/03/22)
In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
A new strategy for the preparation of secondary amines via o- (tetrahydropyranyloxymethyl)-benzamides
Fichert, Thomas,Massing, Ulrich
, p. 5017 - 5018 (2007/10/03)
The new synthesis strategy for the preparation of secondary amines starts from N-alkyl-phthalimides which are reduced to the corresponding o- hydroxymethyl-N-alkyl-benzamides. After protection of the hydroxy group as tetrahydropyranyl ether the N-alkyl-benzamides are alkylated to o- (tetrahydropyranyloxymethyl)-N,N-dialkyl-benzamides. The deprotection of the hydroxy group and the release of the secondary amines can be achieved in execellent yields in one reaction step using aqueous acetic acid.