39979-08-3

Basic information

• Product Name: 7-Aminoheptanoic acid methyl ester
• Synonyms: 7-Aminoheptanoic acid methyl ester
• CAS NO: 39979-08-3
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159
• Mol File: 39979-08-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 211℃
• Flash Point: 81℃
• Appearance: /
• Density: 0.949
• PKA: 10.58±0.10(Predicted)
• CAS DataBase Reference: 7-Aminoheptanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Aminoheptanoic acid methyl ester(39979-08-3)
• EPA Substance Registry System: 7-Aminoheptanoic acid methyl ester(39979-08-3)

Safety Data

• Hazardous Substances Data: 39979-08-3(Hazardous Substances Data)

Usage

General Description

7-Aminoheptanoic acid methyl ester, also known as aminocaproic acid methyl ester, is a chemical compound with the molecular formula C8H17NO2. It is derived from caproic acid and contains an amino group, making it a secondary amine. 7-Aminoheptanoic acid methyl ester is commonly used in the production of pharmaceuticals and as a chemical intermediate in organic synthesis. It has a wide range of applications, including as a building block in the synthesis of various drugs and in the formulation of biochemical buffers. Additionally, it has been studied for its potential pharmacological properties, such as anti-fibrinolytic and antihyperlipidemic effects, making it a candidate for further research and development in the pharmaceutical industry.

Upstream product

• 67-56-1 methanol 
• 60142-89-4 7-[(tert-butoxycarbonyl)amino]heptanoic acid 
• 111-26-2 hexan-1-amine 
• 201230-82-2 carbon monoxide 
• 13154-41-1 methyl 7-nitroheptanoate 
• 929-17-9 7-aminoheptanoic acid 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 143-33-9 sodium cyanide 

Relevant articles and documents

Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group

Psammaplin A (PsA) is a bromotyrosine disulfide dimer with histone deacetylase (HDAC) inhibition and acts through reduced monomer PsA-SH. We studied the connection of HDAC inhibition, cell growth inhibition, and apoptosis induction of PsA-SH by modifying the -SH group with deletion (6a) or replacement with hydroxamic acid (10b) or benzamide (12g). PsA-SH inhibits HDAC1/2/3 and 6a loses the HDAC inhibition ability. 10b inhibits HDAC1/2/3/6 while 12g shows selective inhibition of HDAC3. PsA-SH and 10b, but neither 6a nor 12g, induce apoptosis in human leukemia HL-60 cells associated with increased acetylation of Histone H3. PsA-SH and 10b inhibit growth of several solid tumor cell lines in vitro and Lewis lung cancer cell growth in vivo. PsA-SH is a simple scaffold for developing selective HDAC inhibitors and induces apoptosis through inhibiting HDAC1/2.

Electro-organic synthesis of N-hexyl carbamate by carbonylation of methanol and hexylamine with CO over Au supported on carbon anode

It has been found that Au anode, [AuBr3/AC+VGCF], showed the electro-catalysis for carbonylation of methanol, hexylamine and CO to 6-amino-hexyl-carbamic acid methyl ester (N-hexyl carbamate) using LiBr electrolyte.