3999-01-7 Usage
Description
(9Z,12Z)-Octadeca-9,12-dien-1-amide, also known as linoleic acid amide, is a primary fatty acid amide derived from linoleic acid. It is characterized by the presence of two double bonds at the 9th and 12th carbon positions, which give it unique chemical and biological properties. Linoleic acid amide is known to regulate calcium (Ca2+) flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 15-53 μM), which can have significant implications in various biological processes.
Uses
Used in Pharmaceutical Industry:
(9Z,12Z)-Octadeca-9,12-dien-1-amide is used as a bioactive compound for its ability to regulate Ca2+ flux. This property makes it a potential candidate for the development of drugs targeting conditions related to calcium dysregulation, such as certain cardiovascular and neurological disorders.
Used in Cosmetic Industry:
In the cosmetic industry, (9Z,12Z)-octadeca-9,12-dien-1-amide may be used as an ingredient in skincare products due to its potential to modulate cellular processes related to skin health and function. Its ability to regulate Ca2+ flux could be beneficial in developing products that promote skin barrier function and overall skin health.
Used in Research Applications:
(9Z,12Z)-Octadeca-9,12-dien-1-amide is used as a research tool for studying the role of fatty acid amides and their effects on cellular signaling pathways, particularly those involving calcium regulation. This can contribute to a better understanding of various physiological and pathological processes in the body.
Used in Functional Food and Nutrition:
(9Z,12Z)-Octadeca-9,12-dien-1-amide may also be utilized in the development of functional foods and nutraceuticals, where its ability to regulate Ca2+ flux could be leveraged to promote health benefits related to cardiovascular and neurological function.
Check Digit Verification of cas no
The CAS Registry Mumber 3999-01-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,9 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3999-01:
(6*3)+(5*9)+(4*9)+(3*9)+(2*0)+(1*1)=127
127 % 10 = 7
So 3999-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H33NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H2,19,20)/b7-6-,10-9-
3999-01-7Relevant articles and documents
A Convenient Protocol for the Synthesis of Fatty Acid Amides
Johansson, Silje J. R.,Johannessen, Tonje,Ellefsen, Christiane F.,Ristun, Mali S.,Antonsen, Simen,Hansen, Trond V.,Stenstrom, Yngve,Nolsoe, Jens M. J.
supporting information, p. 213 - 217 (2019/01/14)
Several classes of biologically occurring fatty acid amides have been reported from mammalian and plant sources. Many amides conjugated with fatty acids of mammalian origin exhibit specific activation of individual receptors. Their potential as pharmacological tools or as lead compounds towards the development of novel therapeutics is of great interest. Hence, access to such amides by a practical, high-yielding and scalable protocol without affecting the geometry or position of sensitive functionalities is needed. A protocol that meets all these requirements involves activation of the corresponding acid with carbonyl diimidazole (CDI) followed by reaction with the desired amine or its hydrochloride. More than fifty compounds have been prepared in generally high yields.
The invention of radical reactions. Part XXIII new reactions: Nitrile and thiocyanate transfer to carbon radicals from sulfonyl cyanides and sulfonyl isothiocyanates
Barton,Jaszberenyi,Theodorakis
, p. 2613 - 2626 (2007/10/02)
Reaction of p-toluenesulphonyl cyanide or methanesulfonyl cyanide with carbon radicals, generated from the corresponding O-acyl-N-hydroxy-2-thiopyridone derivatives by visible light photolysis gives nitriles in good yield. The homolysis products of these sulfonyl nitriles can also be trapped by electron rich olefins. We have also found that carbon radicals react easily with mesyl or tosyl isothiocyanate producing thiocyanates.
