39998-25-9Relevant articles and documents
7-azabenzofuran derivatives and application thereof in antitumor drugs
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Paragraph 0031-0033, (2021/01/29)
The invention discloses a 7-azabenzofuran compound with anti-tumor activity and a synthesis method of the 7-azabenzofuran compound. The key synthesis step is that pyridine oxynitride is used as a substrate and reacts with acyl chloride to generate the 7-azabenzofuran derivative. An anti-tumor activity test proves that the 7-azabenzofuran derivative provided by the invention has strong anti-tumor activity on various tumor cells, including human leukemia cells K562, human hepatoma carcinoma cells HepG2 and human colon cancer cells HCT116, and is expected to be developed into a new anti-tumor drug.
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY
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Page/Page column 146, (2019/09/18)
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol "APLNR"). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) cardiovascular disease; (ii) metabolic disorders; (iii) diseases, disorders, and conditions associated with vascular pathology; and (iv) organ failure; (v) diseases, disorders, and conditions associated with infections (e.g., microbial infections); and (vi) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include pulmonary hypertension (e.g., PAH); heart failure; type II diabetes; renal failure; sepsis; and systemic hypertension.
Chemoselective photochemical surface reaction - Ketene versus carbene reactivity from the photolysis of saturated monolayers of pyridyl diazoesters on single-crystal Pt
Pitters, Jason L.,Adkinson, Dana K.,Griffiths, Keith,Norton, Peter R.,Workentin, Mark S.
experimental part, p. 117 - 121 (2011/04/23)
Irradiation of saturated monolayers of 3-and 4-substituted pyridyl diazoacetates on single-crystal Pt surfaces leads to either the corresponding reactive carbene or stable ketene intermediate with the chemoselectivity determined by the position of the photoreactive substituent on the pyridyl ring, which ultimately directs the available interactions with neighboring substrates.