400091-57-8

Basic information

• Product Name: 2H-Pyran, 2-[2-chloro-4-(trifluoromethyl)phenoxy]tetrahydro-
• CAS NO: 400091-57-8
• Molecular Formula: C12H12ClF3O2
• Molecular Weight: 280.674
• Mol File: 400091-57-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, 2-[2-chloro-4-(trifluoromethyl)phenoxy]tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, 2-[2-chloro-4-(trifluoromethyl)phenoxy]tetrahydro-(400091-57-8)
• EPA Substance Registry System: 2H-Pyran, 2-[2-chloro-4-(trifluoromethyl)phenoxy]tetrahydro-(400091-57-8)

Safety Data

• Hazardous Substances Data: 400091-57-8(Hazardous Substances Data)

Upstream product

• 134142-88-4 2-[(4-trifluoromethyl)phenoxy]tetrahydro-2H-pyrane 
• 402-45-9 4-hydroxybenzotrifluoride 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 35852-58-5 2-chloro-4-trifluoromethylphenol 

Relevant articles and documents

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, inflammatory disease of the joints, neuropathies, HIV-related neuropathy, nerve injury, neurodegeneration, stroke, urinary bladder hypersensitivity including urinary incontinence, cystitis, stomach duodenal ulcer, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), fecal urgency, gastro-esophageal reflux disease (GERD), Crohn's disease, asthma, chronic obstructive pulmonary disease, cough, neurotic/allergic/inflammatory skin disease, psoriasis, pruritus, prurigo, irritation of skin, eye or mucous membrane, hyperacusis, tinnitus, vestibular hypersensitivity, episodic vertigo, cardiac diseases such as myocardial ischemia, hair growth-related disorders such as effluvium, alopecia, rhinitis, and pancreatitis.

2-Substituted 4-(trifluoromethyl)phenols by directed ortho-lithiation

A broad variety of 2-substituted 4-(trifluoromethyl)phenols can be prepared in a large scale by o-lithiation and reaction with electrophiles in good to excellent yields. The key for the selectivity is the superior ortho-directing effect of the THP-protect