40016-26-0Relevant articles and documents
Synthesis of Fingolimod Employing Regioselective Aziridine Ring-Opening Reaction as a Key Step
Cinibulk, Josef,Doubsky, Jan,Klvaňa, Robert,Rádl, Stanislav
, (2021/09/18)
An efficient and scalable synthesis of the immunomodulating drug fingolimod hydrochloride has been developed with the aziridine regioselective ring-opening reaction as a key step. This manuscript describes design, detailed synthetic route scouting, and optimization study of the aziridine ring-opening reaction. As a starting material for the polar part of the fingolimod molecule, cheap, common, and widely commercially available tris(hydroxymethyl)aminomethane was used. n-Octyl group was introduced into the molecule either via Kumada or Negishi cross-couplings, or alternatively by Sonogashira cross-coupling followed by hydrogenation. The final step consists of a one-pot acidic deprotection both of the acetonide and Boc group, providing thus highly pure fingolimod hydrochloride from the crude reaction mixture directly. The described process is highly effective, is industrially applicable, and has been successfully applied to 500 g scales of the target product.
ANTIMICROBIAL AND SURFACE-ACTIVE PROPERTIES OF CATIONIC SURFACTANTS BASED ON CHLOROALKANES AND ALKYLBENZENES
Chernyavskaya, M. A.,Stefanovich, V. V.,Sergeeva, I. A.,Belova, A. S.
, p. 784 - 787 (2007/10/02)
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