40016-69-1

Basic information

• Product Name: Carbamic chloride, (1-methylethyl)phenyl-
• CAS NO: 40016-69-1
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Mol File: 40016-69-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic chloride, (1-methylethyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic chloride, (1-methylethyl)phenyl-(40016-69-1)
• EPA Substance Registry System: Carbamic chloride, (1-methylethyl)phenyl-(40016-69-1)

Safety Data

• Hazardous Substances Data: 40016-69-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 1124-52-3 N-(propan-2-ylidene)aniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 768-52-5 N-Isopropylaniline 
• 75-44-5 phosgene 

Downstream Products

• 202415-36-9 1-(2,2-dimethoxyethyl)-4-(N-isopropyl-N-phenylcarbamoyl)-5(4H)-tetrazolinone 
• 1312718-56-1 C₁₇H₂₄N₂O₂ 
• 1350912-14-9 5,5-dimethyl-3-phenylhex-1-yn-3-yl isopropylcarbamate 
• 1350911-32-8 1-(4-methoxyphenyl)vinyl isopropylphenylcarbamate 
• 1350911-25-9 1-phenylvinyl isopropylphenylcarbamate 
• 1350911-29-3 1-(4-chlorophenyl)vinyl isopropylphenylcarbamate 
• 1350911-12-4 vinyl isopropylphenylcarbamate 
• 1350912-22-9 1-(dimethyl(phenyl)silyl)hexyl isopropylphenylcarbamate 
• 1350911-58-8 1-(dimethyl(phenyl)silyl)vinyl isopropylphenylcarbamate 
• 1350911-56-6 (E)-4-phenylbuta-1,3-dien-2-yl isopropylphenylcarbamate 
• 1350911-54-4 4-phenylbut-1-en-3-yn-2-yl isopropylphenylcarbamate 
• 1350911-52-2 4-(trimethylsilyl)but-1-en-3-yn-2-yl isopropylphenylcarbamate 
• 1350911-51-1 4-(triisopropylsilyl)but-1-en-3-yn-2-yl isopropylphenylcarbamate 
• 1350911-41-9 5,5-dimethylhex-1-en-3-yn-2-yl isopropylphenylcarbamate 

Relevant articles and documents

Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)?H Carbamoylation

A general and user-friendly synthesis of β-lactams is reported that makes use of Pd0-catalyzed carbamoylation of C(sp3)?H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C?H bonds, in contrast to previous methods based on C(sp3)?H activation. In addition, the feasibility of an enantioselective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free β-lactams and β-amino acids.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.