4004-97-1 Usage
Chemical class
Piperazine derivatives It belongs to a group of chemical compounds that have a piperazine ring in their structure.
Usage
Research and pharmaceutical synthesis It is commonly used in research settings as a building block for the synthesis of various pharmaceutical compounds and as a precursor for the preparation of bioactive molecules.
Chemical structure
Piperazine ring, fluorophenyl group, and p-tolylsulphonyl group These structural elements are important for the compound's chemical reactivity and biological activity.
Reactivity
Influenced by the presence of the fluorophenyl and p-tolylsulphonyl groups The presence of these functional groups allows for various chemical reactions and modifications, making it a versatile compound for synthesis.
Biological activity
Potential as a precursor for bioactive molecules Due to its unique structure, it can be used as a starting point for the development of new bioactive compounds with potential applications in medicine.
Importance in medicinal chemistry
Valuable tool in drug discovery The compound's unique structure and reactivity make it a valuable tool for researchers in the field of medicinal chemistry and drug discovery.
Solubility
Not mentioned in the material The solubility of the compound is not provided in the given material, but it is an important property to consider when working with chemical compounds.
Stability
Not mentioned in the material The stability of the compound under various conditions (e.g., temperature, pH) is not provided in the given material, but it is a crucial factor to consider for its practical applications.
Safety and handling
Not mentioned in the material Information on the safety and handling precautions for this compound is not provided in the given material, but it is essential to know when working with any chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 4004-97-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,0 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4004-97:
(6*4)+(5*0)+(4*0)+(3*4)+(2*9)+(1*7)=61
61 % 10 = 1
So 4004-97-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H19FN2O2S/c1-14-2-8-17(9-3-14)23(21,22)20-12-10-19(11-13-20)16-6-4-15(18)5-7-16/h2-9H,10-13H2,1H3
4004-97-1Relevant articles and documents
Rapid Synthesis of N,N'-Disubstituted Piperazines. Application to the Preparation of No Carrier Added 1-(4-Fluorophenyl)piperazine and of an -Selective Ligand of Serotoninergic Receptors (5HT2 antagonist)
Collins, Michael,Lasne, Marie-Claire,Barre, Louisa
, p. 3185 - 3188 (2007/10/02)
An efficient and rapid method of piperazine formation (>50percent, 30 min) involving the reaction of N,O,O'-tris(toluene-p-sulfonyl)bis(2-hydroxyphenyl)amine 3 and 4-fluoroaniline in an alcohol or in hexamethylphosphoramide has been developed.It has been applied to the preparation of 1-(4-fluorophenyl)piperazine 6b, a new precursor in (18F)-labelling for positron emission tomography studies.Compound 6b was obtained in 7-15percent decay corrected radiochemical yield in a synthesis time of 145-165 min counted from the labelled precursor fluoride and a radiochemical purity greater than 98percent after HPLC purification.The utility of 6b was demonstrated by the synthesis of the naphtosultam 8b, a selective antagonist of 5-HT2 receptors.Compound 8b was obtained radiochemically pure in 50 min from 6b (including HPLC) and in an overall yield of 2.5-12percent (decay corrected) from fluoride.
