4005-02-1

Basic information

• Product Name: ETHYL 4-(2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)BENZOATE
• Synonyms: ETHYL 4-(2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)BENZOATE
• CAS NO: 4005-02-1
• Molecular Formula: C₁₈H₁₆N₂O₃
• Molecular Weight: 308.33
• Mol File: 4005-02-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 488.4°Cat760mmHg
• Flash Point: 249.2°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 1.1E-09mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: ETHYL 4-(2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)BENZOATE(4005-02-1)
• EPA Substance Registry System: ETHYL 4-(2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)BENZOATE(4005-02-1)

Safety Data

• Hazardous Substances Data: 4005-02-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H16N2O3/c1-3-23-18(22)13-8-10-14(11-9-13)20-12(2)19-16-7-5-4-6-15(16)17(20)21/h4-11H,3H2,1-2H3

Upstream product

• 348-06-1 p-carboethoxybenzenediazonium tetrafluoroborate 
• 134-20-3 2-carbomethoxyaniline 
• 75-05-8 acetonitrile 
• 4005-05-4 4-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid 
• 64-17-5 ethanol 
• 863988-62-9 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoyl chloride 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 65268-66-8 4-{2-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl}-benzoic acid ethyl ester 
• 65223-95-2 4-{2-[(E)-2-(2-Chloro-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl}-benzoic acid ethyl ester 
• 65224-01-3 4-{2-[(E)-2-(3-Nitro-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl}-benzoic acid ethyl ester 
• 65224-02-4 4-{2-[(E)-2-(4-Nitro-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl}-benzoic acid ethyl ester 
• 65223-94-1 4-[4-Oxo-2-((E)-styryl)-4H-quinazolin-3-yl]-benzoic acid ethyl ester 
• 65223-97-4 4-{2-[(E)-2-(3-Hydroxy-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl}-benzoic acid ethyl ester 
• 10073-94-6 4-(2-methyl-4-oxoquinazoline-3-yl)benzoic acid hydrazide 
• 1898-06-2 3-amino-2-methyl-4-oxoquinazoline 
• 5351-17-7 4-aminobenzohydrazide 
• 93574-70-0 C₂₁H₂₃N₅O₂S 
• 93574-08-4 C₂₃H₁₉N₅O₂S 
• 93574-09-5 C₂₄H₂₁N₅O₂S 
• 93574-10-8 C₂₄H₂₁N₅O₂S 
• 126938-35-0 2-Phenyl-2,3-dihydropyrazolo[5,1-b] quinazolin-9(1H)-one 

Relevant articles and documents

Preparation of 4(3H)-quinazolinones from aryldiazonium salt, nitriles and 2-aminobenzoate via a cascade annulation

One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone.

Potential biologically active agents: VIII. Synthesis of 2 methyl (and styryl) 3 aryl 4 (3H) quinazolones

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