400744-49-2

Basic information

• Product Name: 3'-CHLOROBIPHENYL-4-CARBALDEHYDE
• Synonyms: 3'-CHLORO[1,1'-BIPHENYL]-4-CARBALDEHYDE;3'-CHLORO-[1,1'-BIPHENYL]-4-CARBOXALDEHYDE;3'-CHLOROBIPHENYL-4-CARBALDEHYDE;AKOS BAR-0054;[1,1'-DIPHENYL]-4-CARBOXALDEHYDE, 3'-CHLORO-;4-(3-Chlorophenyl)benzaldehyde;[1,1'-Biphenyl]-4-carboxaldehyde, 3'-chloro-;3'-Chloro-4-formylbiphenyl, 4-(3-Chlorophenyl)benzaldehyde
• CAS NO: 400744-49-2
• Molecular Formula: C13H9ClO
• Molecular Weight: 216.66
• Mol File: 400744-49-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 357.8 °C at 760 mmHg
• Flash Point: 185.2 °C
• Appearance: /
• Density: 1.215 g/cm³
• CAS DataBase Reference: 3'-CHLOROBIPHENYL-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-CHLOROBIPHENYL-4-CARBALDEHYDE(400744-49-2)
• EPA Substance Registry System: 3'-CHLOROBIPHENYL-4-CARBALDEHYDE(400744-49-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 400744-49-2(Hazardous Substances Data)

Usage

Uses

3''-Chlorobiphenyl-4-carbaldehyde

Upstream product

• 63503-60-6 3-chlorophenylboronic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 108-37-2 1-bromo-3-chlorobenzene 
• 87199-17-5 4-formylphenylboronic acid, 
• 1122-91-4 4-bromo-benzaldehyde 
• 93308-05-5 7-<3-Chlor-phenyl>-tropiliden 

Downstream Products

• 1382978-22-4 C₁₈H₁₉ClN₂O₂ 
• 1413776-83-6 C₂₅H₃₃ClN⁽¹⁺⁾*I^(1-) 
• 1413776-95-0 C₂₅H₃₁ClN⁽¹⁺⁾*I^(1-) 
• 1413776-89-2 1-(3'-chlorobiphenyl-4-yl)-N-(((1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-3-yl)methyl)-N,N-dimethylmethanaminium iodide 
• 1462885-96-6 (R)-3-{N-(3'-chlorobiphenyl-4-ylmethyl)-N'-[3-(4-methoxybenzyloxy)isoxazole-5-carbonyl]hydrazino}-2-hydroxypropionic acid isopropyl ester 
• 1419403-58-9 7-(3-chlorophenyl)-3-methyl-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione 
• 1419403-55-6 ethyl 6-(3-chlorophenyl)-3-(ethoxycarbonylamino)-1H-indole-2-carboxylate 
• 1419403-51-2 ethyl 3-amino-6-(3-chlorophenyl)-1H-indole-2-carboxylate 
• 1419403-49-8 ethyl 6-(3-chlorophenyl)-3-(phenyldiazenyl)-1H-indole-2-carboxylate 
• 1419403-47-6 ethyl 6-(3-chlorophenyl)-1H-indole-2-carboxylate 

Relevant articles and documents

Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement

Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.

The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both in Vitro and in Vivo

The transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer, and neurodegenerative diseases. However, the limit of specific inhibitors impedes the development of TRPM2-targeted therapeutic agents. To discover more potent and selective TRPM2 inhibitors, 59 N-(p-amylcinnamoyl) anthranilic acid (ACA) derivatives were synthesized and evaluated using calcium imaging and electrophysiology approaches. Systematic structure-activity relationship studies resulted in some potent compounds inhibiting the TRPM2 channel with sub-micromolar half-maximal inhibitory concentration values. Among them, the preferred compound A23 exhibited TRPM2 selectivity over TRPM8 and TRPV1 channels as well as phospholipase A2 and showed neuroprotective activity in vitro. Following pharmacokinetic studies, A23 was further evaluated in a transient middle cerebral artery occlusion model in vivo, which significantly reduced cerebral infarction. These data indicate that A23 might serve as a useful tool for TRPM2-related research as well as a lead compound for the development of therapeutic agents for ischemic injury.

N,S-chelating triazole-thioether ligand for highly efficient palladium-catalyzed Suzuki reaction

1,2,3-Triazole-thioether compounds could serve as efficient ligands for Pd-catalyzed Suzuki reactions of various aryl iodides, bromides and chlorides. The reactions feature wide substrate scope and mild reaction conditions. Besides, shorter reaction time, lower catalyst loadings and quantitative yields with a turnover-frequency (TOF) value of up to 11,880 h?1 are other advantageous of this attractive protocol. The crystal structure analyses and computational studies revealed that the higher catalytic activity of the corresponding chelated palladium complex ascribed to the lower energy gap and the lower redox potential.