400839-43-2

Basic information

• Product Name: N-Cyclopropyl-2-nitrobenzenesulfonamide
• Synonyms: N-Cyclopropyl-2-nitrobenzenesulfonamide;CBDivE_014668;ST5438150;ZINC00300796
• CAS NO: 400839-43-2
• Molecular Formula: C₉H₁₀N₂O₄S
• Molecular Weight: 242.2517
• Mol File: 400839-43-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Cyclopropyl-2-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclopropyl-2-nitrobenzenesulfonamide(400839-43-2)
• EPA Substance Registry System: N-Cyclopropyl-2-nitrobenzenesulfonamide(400839-43-2)

Safety Data

• Hazardous Substances Data: 400839-43-2(Hazardous Substances Data)

Usage

General Description

N-Cyclopropyl-2-nitrobenzenesulfonamide is a chemical compound that is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is a sulfonamide derivative with a cyclopropyl group and a nitro group attached to a benzene ring. N-Cyclopropyl-2-nitrobenzenesulfonamide is known for its antimicrobial and antiparasitic properties, and it has been studied for its potential use in the treatment of various infections and diseases. N-Cyclopropyl-2-nitrobenzenesulfonamide is also used as a reagent in organic synthesis and as an intermediate in the production of other chemical compounds. Additionally, it is important to handle this compound with caution due to its potential health and environmental hazards.

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 1399849-39-8 N-cyclopropyl-N-[1-(2-naphthyl)ethyl]-2-nitrobenzenesulfonamide 
• 1097920-43-8 N-cyclopropyl-N-methyl-2-nitrobenzenesulfonamide 

Relevant articles and documents

Synthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) – An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity

We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), essential for the survival of the eukaryotic parasite Trypanosoma brucei responsible for Human African Trypanosomiasis (HAT). The lead compound, 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (1, also known as MDL 73811, or AbeAdo), has curative efficacy at a low dosage in a hemolymphatic model of HAT but displayed no demonstrable effect in a mouse model of the CNS stage of HAT due to poor blood–brain barrier permeation. Therefore, we prepared and evaluated an extensive set of analogs with modifications in the aminobutenyl side chain, the 5′-amine, the ribose, and the purine fragments. Although we gained valuable structure–activity insights from this comprehensive dataset, we did not gain traction on improving the prospects for CNS penetration while retaining the potent antiparasitic activity and metabolic stability of the lead compound 1.

BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF

The present invention provides a compound represented by the formula: wherein R1 is an acyl group, R2 is a hydrocarbon group which may be substituted or the like, R3 is a hydrocarbon group which may be substituted or the like, R4 is a hydrocarbon group which may be substituted or the like, n is from 0 to 4, and X is an oxygen atom, a sulfur atom or the like, or a salt thereof. The invention also provides a compound which has a TGR23 antagonist activity and thus is useful for prevention and treatment of cancer.

Heterocyclic substituted 2-methyl-benzimidazole antiviral agents

The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus infection.