400882-07-7 Usage
Description
Cyflumetofen is an acracide and insecticide with low aqueous solubility and non-toxic properties. It is not persistent in the environment and has low toxicity to honeybees, but moderate to high toxicity to most other biodiversity. Its oral mammalian toxicity is also low.
Uses
Used in Agriculture:
Cyflumetofen is used as an insecticide for controlling various pests in agricultural crops. Its low toxicity to honeybees and non-persistence in the environment make it a preferred choice for sustainable farming practices.
Used in Environmental Protection:
Due to its low mammalian toxicity and non-persistent nature, Cyflumetofen is used in environmental protection efforts to control insect populations without causing significant harm to other species or the ecosystem.
Used in Public Health:
Cyflumetofen's insecticidal properties make it useful in public health initiatives to control disease-carrying insects, such as mosquitoes, which can transmit illnesses like malaria, dengue, and Zika virus. Its low toxicity to mammals ensures minimal risk to humans and other non-target species during these applications.
Biological Activity
It has been shown to inhibit the activity of detoxification enzymes and mitochondrial membrane potential, which may be responsible for its toxicity in insects. Cyflumetofen also causes a synergic effect with other chemicals, such as pesticides, by increasing their toxicity to insects.
Mechanism of action
cyflumetofen inhibited mitochondria complex II in mites. In addition, the de-esterified form (AB-1) of cyflumetofen inhibited mitochondria complex II at extremely low concentrations. AB-1 was also detected as the main metabolite in mites. The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities.
Check Digit Verification of cas no
The CAS Registry Mumber 400882-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,8,8 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 400882-07:
(8*4)+(7*0)+(6*0)+(5*8)+(4*8)+(3*2)+(2*0)+(1*7)=117
117 % 10 = 7
So 400882-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H24F3NO4/c1-22(2,3)16-9-11-17(12-10-16)23(15-28,21(30)32-14-13-31-4)20(29)18-7-5-6-8-19(18)24(25,26)27/h5-12H,13-14H2,1-4H3
400882-07-7Relevant articles and documents
Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement
Beadle, Ryan,Cheng, Jiagao,Earley, Fergus G.,Li, Zhong,Maienfisch, Peter,Zhou, Cong
, (2020/04/30)
The application of a carbon-silicon bioisosteric replacement strategy to find new acaricides with improved properties led to the discovery of Sila-Cyflumetofen 6B, a novel and highly potent acaricide. The essential t-butyl group in the beta-ketonitrile ac