401-55-8 Usage
Description
Ethyl bromofluoroacetate is a clear yellow liquid that serves as an essential intermediate in the chemical synthesis process. It is known for its role in creating polyfluoroalkyl-substituted fluoro enol ethers and N-protected α-fluoroglycines, which are significant compounds in various chemical and pharmaceutical applications.
Uses
Used in Chemical Synthesis:
Ethyl bromofluoroacetate is used as an intermediate for the synthesis of polyfluoroalkyl-substituted fluoro enol ethers. These enol ethers are valuable in the creation of various chemical compounds due to their unique properties and reactivity.
Ethyl bromofluoroacetate is also used as an intermediate in the synthesis of N-protected α-fluoroglycines. These α-fluoroglycines are important building blocks in the development of pharmaceuticals, particularly in the design of new drugs with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 401-55-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 401-55:
(5*4)+(4*0)+(3*1)+(2*5)+(1*5)=38
38 % 10 = 8
So 401-55-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H6BrFO2/c1-2-8-4(7)3(5)6/h3H,2H2,1H3/t3-/m0/s1
401-55-8Relevant articles and documents
Elkik,Imbeaux-Oudotte
, p. 3793 (1978)
Synthesis of phenyl and ester substituted vinyl fluorides via reduction and olefination of esters
Tsai, Hou-Jen,Burton, Donald J.
, p. 135 - 145 (2007/10/03)
A reduction-olefination sequence has been used to convert ethyl pentafluoropropanoate 6 to 1-fluoro-1-phenyl-2-pentafluoroethyl ethene 7 and ethyl 2,4,4,5,5,5-hexafluoro-2-pentenoate 8. Addition of lithium diethyl α-fluorobenzylphosphonate [(EtO)2P(O)CFPh]- Li+ 4 or lithium fluorocarboethoxymethylene dialkylphosphonate [(RO)2P(O)CFCO2Et]- Li+ 5 (R = Et, i-Pr) to a THF solution of fluorinated aldehydes prepared in situ from 6 and diisobutylaluminum hydride (DIBAL) affords the vinyl fluorides C2F5CH=CFPh 7 and C2F5CH=CFCO2Et 8 in good yields. However, yields of the final products 7 and 8 are low when in situ reduction of 6 to aldehyde was performed in the presence of lithium salts of 4 or 5.
A Convenient Synthesis of Ethyl (Diethoxyphosphoryl)fluoroacetate from Ethyl Fluoroacetate
Elkik, Elias,Imbeaux, Michele
, p. 861 - 862 (2007/10/02)
A new synthesis of ethyl (diethoxyphosphoryl)fluoroacetate starting from ethyl fluoroacetate is described for a mole scale.This synthesis does not require the use of special equipment for fluorine chemistry since no hydrogen fluoride is evolved.