40117-28-0Relevant articles and documents
Reactivities of MeO-substituted PBN-type nitrones
Deletraz, Ana?s,Zéamari, Kamal,Di Meo, Florent,Fabre, Paul-Louis,Reybier, Karine,Trouillas, Patrick,Tuccio, Béatrice,Durand, Grégory
, p. 15754 - 15762 (2019/10/28)
In this work, α-phenyl-N-tert-butylnitrone (PBN), N-benzylidene-1-diethoxyphosphoryl-1-methylethylamine N-oxide (PPN) and N-benzylidene-1-ethoxycarbonyl-1-methylethylamine N-oxide (EPPN) derivatives bearing methoxy groups (MeO-) on the phenyl ring were sy
Dual Role of Pyrrolidine and Cooperative Pyrrolidine/Pyrrolidinium Effect in Nitrone Formation
Morales, Sara,Guijarro, Fernando G.,Alonso, Inés,García Ruano, José Luis,Cid, M. Belén
, p. 84 - 91 (2016/01/12)
The formation of nitrones by direct condensation between equimolecular amounts of N-substituted hydroxylamine hydrochlorides and aromatic or aliphatic aldehydes is efficiently promoted by pyrrolidine in a matter of minutes under very mild conditions in almost quantitative yields after a simple filtration through a short pad of silica gel. According to theoretical, spectroscopic, and experimental studies, this success is due to the ability of pyrrolidine to liberate the hydrochloride of the hydroxylamine and catalyze the reaction via iminium activation ion. Moreover, a cooperative pyrrolidine/pyrrolidinium chloride effect facilitates several steps of the catalytic cycle through proton transfer without hampering the nucleophilicity of the hydroxylamine by protonation.
PBN (phenyl-N-tert-butylnitrone)-derivatives are effective in slowing the visual cycle and rhodopsin regeneration and in protecting the retina from light-induced damage
Stiles, Megan,Moiseyev, Gennadiy P.,Budda, Madeline L.,Linens, Annette,Brush, Richard S.,Qi, Hui,White, Gary L.,Wolf, Roman F.,Ma, Jian-Xing,Floyd, Robert,Anderson, Robert E.,Mandal, Nawajes A.
, (2016/02/18)
A2E and related toxic molecules are part of lipofuscin found in the retinal pigment epithelial (RPE) cells in eyes affected by Stargardt's disease, age-related macular degeneration (AMD), and other retinal degenerations. A novel therapeutic approach for t