4014-82-8

Basic information

• Product Name: 10-hydroxydesipramine
• Synonyms: 10-hydroxydesipramine
• CAS NO: 4014-82-8
• Molecular Formula: C18H22N2O
• Molecular Weight: 282.38008
• Mol File: 4014-82-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 439°C at 760 mmHg
• Flash Point: 219.3°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 1.75E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 10-hydroxydesipramine(CAS DataBase Reference)
• NIST Chemistry Reference: 10-hydroxydesipramine(4014-82-8)
• EPA Substance Registry System: 10-hydroxydesipramine(4014-82-8)

Safety Data

• Hazardous Substances Data: 4014-82-8(Hazardous Substances Data)

Usage

Description

10-Hydroxydesipramine is a derivative of the compound Desipramine (CAS#50-47-5), which is a potent tricyclic antidepressant. It possesses a hydroxyl group at the 10th position, enhancing its pharmacological properties. This modification allows 10-hydroxydesipramine to exhibit improved efficacy in treating depressive disorders by selectively inhibiting the norepinephrine transporter, thereby increasing the availability of norepinephrine in the synaptic cleft.

Uses

Used in Pharmaceutical Industry:
10-Hydroxydesipramine is used as an antidepressant for the treatment of major depressive disorder and other mood-related conditions. Its application is based on its ability to selectively inhibit the norepinephrine transporter, leading to an increase in norepinephrine levels in the brain, which is associated with improved mood and reduced depressive symptoms.
Additionally, due to its structural similarity to Desipramine, 10-hydroxydesipramine may also be used in research and development for the creation of novel antidepressant drugs with potentially better efficacy, fewer side effects, or improved pharmacokinetic properties.

InChI:InChI=1/C18H22N2O/c1-19-11-6-12-20-16-9-4-2-7-14(16)13-18(21)15-8-3-5-10-17(15)20/h2-5,7-10,18-19,21H,6,11-13H2,1H3