401568-12-5

Basic information

• Product Name: C₂₄H₃₄N₄O₅S
• CAS NO: 401568-12-5
• Molecular Weight: 490.624
• Mol File: 401568-12-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₄N₄O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₄N₄O₅S(401568-12-5)
• EPA Substance Registry System: C₂₄H₃₄N₄O₅S(401568-12-5)

Safety Data

• Hazardous Substances Data: 401568-12-5(Hazardous Substances Data)

Upstream product

• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 401564-30-5 3-[(2S,4R)-1-tert-butoxycarbonyl-4-hydroxy-2-pyrrolidinylcarbonyl]-1,3-thiazolidine 
• 401564-36-1 (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 
• 26905-03-3 4-(4-Nitrophenyl)piperidine 

Relevant articles and documents

[(S)-γ-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors

In the search for an inhibitor of dipeptidyl peptidase IV (DPP-IV) highly potent both in vitro and in vivo, we synthesized a series of l-prolylthiazolidine-based DPP-IV inhibitors having 4-arylpiperazine or 4-arylpiperidine at the γ-position of the proline structure. Of these compounds, the 4-(5-nitro-2-pyridyl)piperazine analog 21e showed a sub-nanomolar (IC50 = 0.92 nmol/L) DPP-IV inhibitory activity and a long-lasting in vivo DPP-IV inhibition profile.