401647-91-4

Basic information

• Product Name: ethyl N-[(2-acetyl-3-oxo-1-phenyl)but-1-yl]carbamate
• Synonyms: ethyl N-[(2-acetyl-3-oxo-1-phenyl)but-1-yl]carbamate
• CAS NO: 401647-91-4
• Molecular Weight: 277.32
• Mol File: 401647-91-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl N-[(2-acetyl-3-oxo-1-phenyl)but-1-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-[(2-acetyl-3-oxo-1-phenyl)but-1-yl]carbamate(401647-91-4)
• EPA Substance Registry System: ethyl N-[(2-acetyl-3-oxo-1-phenyl)but-1-yl]carbamate(401647-91-4)

Safety Data

• Hazardous Substances Data: 401647-91-4(Hazardous Substances Data)

Upstream product

• 3696-52-4 Ethyl-N-<α-(p-toluolsulfonyl)-benzyl>-carbamat 
• 123-54-6 acetylacetone 
• 100-52-7 benzaldehyde 
• 51-79-6 urethane 

Downstream Products

• 939-03-7 3-methyl-5-phenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

Synthesis of novel 14-membered cyclic bis-semicarbazones

An efficient method for the stereoselective synthesis of novel 14-membered cyclic bis-semicarbazones based on acid-catalyzed cyclization of the hydrazones of 3-(3-oxobutyl)semicarbazides has been developed. The starting semicarbazides were prepared according to a four-step strategy involving amidoalkylation of the sodium enolate of acetylacetone with N-(α-tosylbenzyl)carbamates followed by base-promoted retro-Claisen reaction and treatment of the obtained N-(3-oxobutyl)carbamates with hydrazine.

Different modes of acid-catalyzed cyclization of 4-(γ-oxoalkyl)semicarbazide hydrazones: 7-membered versus 14-membered cyclic semicarbazones formation

Acid-catalyzed cyclization of 4-(γ-oxoalkyl)semicarbazide hydrazones has been studied. 7-Membered cyclic semicarbazones, 2,4,5,6-tetrahydro-3H-1,2,4-triazepin-3-ones, were obtained from the γ-phenyl-substituted semicarbazides, while the cyclization of the γ-methyl-substituted semicarbazides involved two molecules of the starting material to result in 14-membered cyclic bis-semicarbazones, 1,2,4,8,9,11-hexaazacyclotetradeca-7,14-diene-3,10-diones. The 4-(γ-oxoalkyl)semicarbazide hydrazones were prepared according to a four-step synthesis based on amidoalkylation of the sodium enolates of 1,3-diketones with ethyl N-(1-tosylalk-1-yl)carbamates followed by base-promoted retro-Claisen reaction and treatment of the obtained ethyl N-(γ-oxoalkyl)carbamates with hydrazine.