40165-89-7 Usage
Description
rac-3-Hydroxyheptadecanoic Acid, also known as 3-hydroxy Heptadecanoic acid, is a hydroxylated fatty acid that is a component of lipopolysaccharides (LPS) in several species of Gram-negative bacteria. It is found in periodontally diseased human teeth, particularly in smokers, and is also present in the polar lipids of the edible alga Grateloupia turuturu. Interestingly, the levels of this acid are decreased in the feces of patients with Crohn's disease, indicating its potential role in gut health and disease progression.
Uses
Used in Pharmaceutical Applications:
rac-3-Hydroxyheptadecanoic Acid is used as a therapeutic agent for its potential role in treating Crohn's disease. The decreased levels of this acid in the feces of patients with the disease suggest that it may play a crucial role in maintaining gut health and could be a target for therapeutic intervention.
Used in Dental Health Applications:
As rac-3-Hydroxyheptadecanoic Acid is found in periodontally diseased human teeth, particularly in smokers, it can be used as a biomarker for periodontal disease. This can help in the early detection and treatment of periodontal issues, especially in high-risk populations such as smokers.
Used in Nutritional Applications:
Found in the edible alga Grateloupia turuturu, rac-3-Hydroxyheptadecanoic Acid can be used as a nutritional supplement or ingredient in the food industry. Its presence in a healthy, edible source suggests potential benefits for incorporating it into diets for improved health outcomes.
Used in Research Applications:
Due to its presence in Gram-negative bacteria and its association with Crohn's disease, rac-3-Hydroxyheptadecanoic Acid can be used as a research tool for studying the pathogenesis of the disease and the role of gut microbiota in health and disease. This can lead to a better understanding of the underlying mechanisms and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 40165-89-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,1,6 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40165-89:
(7*4)+(6*0)+(5*1)+(4*6)+(3*5)+(2*8)+(1*9)=97
97 % 10 = 7
So 40165-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16(18)15-17(19)20/h16,18H,2-15H2,1H3,(H,19,20)
40165-89-7Relevant articles and documents
Structure of the unusual Sinorhizobium fredii HH103 lipopolysaccharide and its role in symbiosis
Di Lorenzo, Flaviana,Speciale, Immacolata,Silipo, Alba,Alías-Villegas, Cynthia,Acosta-Jurado, Sebastián,Rodríguez-Carvajal, Miguel-ángel,Dardanelli, Marta S.,Palmigiano, Angelo,Garozzo, Domenico,Ruiz-Sainz, José-Enrique,Molinaro, Antonio,Vinardell, José-María
, p. 10969 - 10987 (2021/01/07)
Rhizobia are soil bacteria that form important symbiotic associations with legumes, and rhizobial surface polysaccharides, such as K-antigen polysaccharide (KPS) and lipopolysaccharide (LPS), might be important for symbiosis. Previously, we obtained a mutant of Sinorhizobium fredii HH103, rkpA, that does not produce KPS, a homopolysaccharide of a pseudaminic acid derivative, but whose LPS electrophoretic profile was indistinguishable from that of the WT strain. We also previously demonstrated that the HH103 rkpLMNOPQ operon is responsible for 5-acetamido-3,5,7,9-tetradeoxy-7-(3-hydroxybutyramido)-L-glyc-ero-L-manno-nonulosonic acid [Pse5NAc7(3OHBu)] production and is involved in HH103 KPS and LPS biosynthesis and that an HH103 rkpM mutant cannot produce KPS and displays an altered LPS structure. Here, we analyzed the LPS structure of HH103 rkpA, focusing on the carbohydrate portion, and found that it contains a highly heterogeneous lipid A and a peculiar core oligosaccharide composed of an unusually high number of hexuronic acids containing b-configured Pse5NAc7(3OHBu). This pseudaminic acid derivative, in its a-configuration, was the only structural component of the S. fredii HH103 KPS and, to the best of our knowledge, has never been reported from any other rhizobial LPS. We also show that Pse5NAc7(3OHBu) is the complete or partial epitope for a mAb, NB6-228.22, that can recognize the HH103 LPS, but not those of most of the S. fredii strains tested here. We also show that the LPS from HH103 rkpM is identical to that of HH103 rkpA but devoid of any Pse5NAc7(3OHBu) residues. Notably, this rkpM mutant was severely impaired in symbiosis with its host, Macroptilium atropurpureum.
