40188-88-3Relevant articles and documents
Stimuli responsive hydrogels derived from a renewable resource: synthesis, self-assembly in water and application in drug delivery
Lalitha, Krishnamoorthy,Prasad, Y. Siva,Maheswari, C. Uma,Sridharan, Vellaisamy,John, George,Nagarajan, Subbiah
, p. 5560 - 5568 (2015)
We designed and synthesised coumarin-tris derivatives from a renewable resource and well characterized them using different spectral techniques. The self-assembly of coumarin-tris amphiphiles into hydrogels was examined relative to the molecular structure
Structural, photophysical and electrochemical properties of a novel cardanol-based salophen ligand and its Mn(II) complex
Sousa, Joyce,Oliveira, Davi R.,Lomonaco, Diego,Correia, Adriana N.,Sousa, Camila Pinheiro,de Lima Neto, Pedro,Paulo, Tércio F.,Mazzetto, Selma E.,Clemente, Claudenilson S.,Mele, Giuseppe
, p. 279 - 286 (2019)
A new cardanol-based salophen (hpbp) ligand and its manganese complex [Mn(hpbp)] were obtained by microwave-assisted synthesis method, with yields and reaction times of 65% in 20 min and 85% in 5min, respectively. The structural features of compounds were
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases
Sahin, Cigdem,Magomedova, Lilia,Ferreira, Thais A. M.,Liu, Jiabao,Tiefenbach, Jens,Alves, Priscilla S.,Queiroz, Fellipe J. G.,Oliveira, Andressa S. De,Bhattacharyya, Mousumi,Grouleff, Julie,Nogueira, Patrícia C. N.,Silveira, Edilberto R.,Moreira, Daniel C.,Leite, José Roberto Souza De Almeida,Brand, Guilherme D.,Uehling, David,Poda, Gennady,Krause, Henry,Cummins, Carolyn L.,Romeiro, Luiz A. S.
, p. 1961 - 1978 (2022/02/14)
Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compounds derived from phenolic lipids present in cashew nut shell liquid (CNSL), an abundant waste byproduct, in an effort to create effective, accessible, and sustainable drugs. Derivatives of anacardic acid and cardanol were tested for PPAR activity in HEK293 cell co-transfection assays, primary hepatocytes, and 3T3-L1 adipocytes. In vivo studies using PPAR-expressing zebrafish embryos identified CNSL derivatives with varying tissue-specific activities. LDT409 (23) is an analogue of cardanol with partial agonist activity for PPARα and PPARγ. Pharmacokinetic profiling showed that 23 is orally bioavailable with a half-life of 4 h in mice. CNSL derivatives represent a sustainable source of selective PPAR modulators with balanced intermediate affinities (EC50 ～100 nM to 10 μM) that provide distinct and favorable gene activation profiles for the treatment of diabetes and obesity.
Cardanol Schiff base antioxidant as well as preparation method and application thereof
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Paragraph 0064-0066, (2020/06/20)
The invention discloses a cardanol Schiff base antioxidant, which comprises a compound having a structure represented by the formula shown in the specification, wherein R is selected from any one of the structures shown in the specification, R1 is independently selected from H or the structure represented by the structure shown in the specification. The invention also discloses a method for preparing the cardanol Schiff base antioxidant. The cardanol Schiff base antioxidant disclosed by the invention has excellent thermal stability and good oxidation resistance and corrosion resistance, the preparation process is simple and feasible, the reaction conditions are mild and rapid, and the aftertreatment is simple and convenient. The cardanol Schiff base antioxidant disclosed by the invention is suitable for being widely applied to the fields of lubricating oil, lubricating grease and the like.
