401909-65-7Relevant articles and documents
Enantioselective approach to 3-substituted prolines
Kamenecka, Theodore M,Park, You-Jung,Lin, Linus S,Lanza Jr., Thomas,Hagmann, William K
, p. 8571 - 8573 (2007/10/03)
Enantioselective synthesis of 3-substituted prolines was achieved starting from commercially available 3-hydroxy-(S)-2-proline. Palladium-mediated couplings were used to introduce a variety of groups at C3 using the corresponding enol triflate derived from N-trityl 3-oxo-(S)-2-proline methyl ester. Cleavage of the trityl residue and hydrogenation provided final products with good to modest diastereoselectivity.