402-93-7Relevant articles and documents
Introducing broadened antibacterial activity to rhodanine derivatives targeting enoyl-acyl carrier protein reductase
Sun, Zhi-Gang,Xu, Yun-Jie,Xu, Jian-Fei,Liu, Qi-Xing,Yang, Yu-Shun,Zhu, Hai-Liang
, p. 125 - 129 (2019/03/28)
Broadened antibacterial activity was introduced to rhodanine derivatives targeting Mycobacterial tuberculosis enoyl-acyl carrier protein reductase (Mtb InhA) by recruiting feature of xacins to bring DNA Gyrase B inhibitory capability. This is significant for preventing further bacterial injections in the tuberculosis treatment. The most potent compound Cy14 suggested comparable bioactivity (IC50=3.18μM for Mtb InhA; IC50=10nM for DNA Gyrase B) with positive controls. Structure–activity relationship discussion and molecular docking model revealed the significance of rhodanine moiety and derived methoxyl on meta-position, pointing out orientations for future modification.
Highly efficient one-pot synthesis, antimicrobial and docking studies of newer β-amino carbonyl derivatives catalyzed by silica sulfuric acid
El-Bayouki,Basyouni,El-Sayed,Tohamy,El-Henawy
, p. 255 - 268 (2013/01/15)
Mannich reaction was applied between 4-fluorobezaldehyde, selected acetophenone and several anilines, catalyzed by silica sulfuric acid for the synthesis of β-amino carbonyl derivatives. Reaction time and yield of the products depended on the nature of ac
Green synthesis of 5-benzylidene rhodanine derivatives catalyzed by 1-butyl-3-methyl imidazolium hydroxide in water
Gong, Kai,He, Zhi-Wei,Xu, Ying,Fang, Dong,Liu, Zu-Liang
experimental part, p. 913 - 915 (2009/09/06)
A basic functionalized ionic liquid, 1-butyl-3-methyl imidazolium hydroxide ([bmim][OH]), catalyzed the Knoevenagel condensation of rhodanine with aromatic aldehydes. It proceeded smoothly in water to afford the 5-benzylidene rhodamine derivatives in high yields at room temperature. This new method offers several advantages, such as excellent yields, short reaction times, and simple procedure. The catalyst can be reused at least 5 times without significant loss of activity.