40207-01-0

Basic information

• Product Name: 3-Methylphenylthiosemicarbazide
• Synonyms: 4-(m-Tolyl)-3-thiosemicarbazide
• CAS NO: 40207-01-0
• Molecular Formula: C₈H₁₁N₃S
• Molecular Weight: 181.25804
• Mol File: 40207-01-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 300.9°Cat760mmHg
• Flash Point: 135.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.699
• PKA: 10.38±0.70(Predicted)
• CAS DataBase Reference: 3-Methylphenylthiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylphenylthiosemicarbazide(40207-01-0)
• EPA Substance Registry System: 3-Methylphenylthiosemicarbazide(40207-01-0)

Safety Data

• Hazardous Substances Data: 40207-01-0(Hazardous Substances Data)

Usage

General Description

3-Methylphenylthiosemicarbazide, also known as 3-Methylthiosemicarbazide, is a chemical compound with the molecular formula C9H12N4S. It is a thiosemicarbazide derivative, which means it contains a sulfur atom bonded to a carbon atom within its structure. 3-Methylphenylthiosemicarbazide is commonly used in chemical research and organic synthesis, particularly in the preparation of various derivatives and related compounds. It has been studied for its potential biological activities, including antiviral and antimicrobial properties. Additionally, 3-Methylphenylthiosemicarbazide has been investigated for its potential use in biocidal and agricultural applications. Overall, this chemical compound has various uses and potential applications in the fields of chemistry and biology.

InChI:InChI=1/C8H11N3S/c1-6-3-2-4-7(5-6)10-8(12)11-9/h2-5H,9H2,1H3,(H2,10,11,12)

Upstream product

• 53278-57-2 m-Toluidino-dithiocarbamyl-essigsaeure 
• 53662-45-6 N-(m-tolyl)-dithiocarbamic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 621-30-7 3-methylphenyl isothiocyanate 

Downstream Products

• 105886-56-4 1-(2-Methyl-4-oxo-4H-quinazolin-3-yl)-3-m-tolyl-thiourea 
• 303215-01-2 C₁₃H₁₂N₄O₂S₂ 
• 934244-61-8 C₂₄H₃₁N₃O₅S 
• 314279-29-3 C₁₆H₁₄N₄OS 
• 1346544-95-3 C₃₃H₄₇N₃O₃S 
• 67420-00-2 N,N'-di-m-tolyl-[1,3,4]thiadiazole-2,5-diamine 
• 41430-88-0 [1,2,3,4]thiatriazol-5-yl-m-tolyl-amine 
• 57165-97-6 3-(4-m-tolyl-thiosemicarbazonomethyl)-rifamycin 
• 52494-32-3 5-(m-methylphenylamino)-1,3,4-thiadiazolium-2-thiolate 
• 2209-27-0 hydrazine-N,N'-dicarbothioic acid bis-(3-methyl-anilide) 
• 103753-99-7 [1,3,4]thiadiazol-2-yl-m-tolyl-amine 
• 7701-04-4 3-phenyl-propenal 4-m-tolyl-thiosemicarbazone 
• 133131-83-6 1-(4-bromo-phenylcarbamoyl)-4-m-tolyl thiosemicarbazide 
• 103989-87-3 3-m-tolylthiocarbamoyl-carbazic acid ethyl ester 

Relevant articles and documents

Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones

In this work, novel 5-fluoro-1-methyl/ethyl-1H-indole-2,3-dione 3-[4-(substituted phenyl)-thiosemicarbazones] 6a-n and 7a-n were synthesized. The antiviral effects of the compounds were tested against HSV-1 (KOS), HSV-2 (G) HSV-1 TK- KOS ACVr and VV in HEL cell cultures using acyclovir and ganciclovir as standards, and Coxsackie B4 virus in Vero cell cultures using ribavirin and mycophenolic acid as standards. R2 ethyl substituted 7 derivatives were found effective against viruses tested. R1 4-CF3 substituted 7d, R1 4-OCH3 substituted 7 g and R1 3-Cl substituted 7 l showed activity against HSV-1 (KOS), HSV-2 (G) HSV-1 TK- KOS ACVr and VV. Whereas only R1 4-Br substituted 7n has selective activity against coxsackie B4 virus. Molecular modeling studies of 7d and 7l were performed to determine binding side on HSV-1 glycoprotein B and D, HSV-2 glycoprotein B structures.

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

Novel bis(thiosemicarbazones) of the 3,5-diacetyl-1,2,4-triazol series and their platinum(ii) complexes: chemistry, antiproliferative activity and preliminary nephrotoxicity studies

The preparation and characterization of three novel 4N- monosubstituted bis(thiosemicarbazone) ligands of 3,5-diacetyl-1,2,4-triazol series and their dinuclear platinum complexes are described. The crystal and molecular structure of the [Pt(μ-H