4023-84-1

Basic information

• Product Name: 4-METHYLBENZALACETONE
• Synonyms: 4-METHYLBENZALACETONE;4-Methylbenzylideneacetone
• CAS NO: 4023-84-1
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.22
• Mol File: 4023-84-1.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 280.6°Cat760mmHg
• Flash Point: 101.3°C
• Appearance: /
• Density: 0.999g/cm³
• Vapor Pressure: 0.00375mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 4-METHYLBENZALACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLBENZALACETONE(4023-84-1)
• EPA Substance Registry System: 4-METHYLBENZALACETONE(4023-84-1)

Safety Data

• Hazardous Substances Data: 4023-84-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H12O/c1-9-3-6-11(7-4-9)8-5-10(2)12/h3-8H,1-2H3/b8-5+

Upstream product

• 104175-13-5 4-(4-methylphenyl)-3-buten-2-ol 
• 104-87-0 4-methyl-benzaldehyde 
• 67-63-0 isopropyl alcohol 
• 1261958-97-7 1-(3-benzyloxybut-1-enyl)-4-methylbenzene 
• 589-18-4 4-Methylbenzyl alcohol 
• 67-64-1 acetone 
• 624-31-7 4-tolyl iodide 
• 78-94-4 methyl vinyl ketone 
• 5720-05-8 4-methylphenylboronic acid 
• 122-00-9 para-methylacetophenone 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 20574-99-6 1-(but-3-en-1-yl)-4-methylbenzene 
• 104-81-4 4-Methylbenzyl bromide 
• 127623-84-1 1-(4-Methylphenyl)-2-butyn-1-ol 

Downstream Products

• 39777-55-4 bis(4-methylstyryl)ketone 
• 143111-92-6 (E)-5-Diethylamino-1-p-tolyl-pent-1-en-3-one; hydrobromide 
• 143111-90-4 (E)-5-Dimethylamino-1-p-tolyl-pent-1-en-3-one; hydrobromide 
• 93626-90-5 1,3-dimethyl-5-p-tolyl-2-aza-1-oxapentadiene 
• 1260430-21-4 C₂₂H₁₉NO₃ 
• 1260430-27-0 C₂₂H₁₈ClNO₃ 
• 1262896-37-6 (2R,3R)-ethyl 2-fluoro-2-nitro-5-oxo-3-p-tolylhexanoate 
• 1262896-25-2 (2S,3R)-ethyl 2-fluoro-2-nitro-5-oxo-3-p-tolylhexanoate 
• 90861-52-2 1H-2-amino-4-toluoylpyrazole 
• 1372610-97-3 1-hydroxy-3-p-tolyl-6H-benzo[c]chromen-6-one 
• 1372611-02-3 1-hydroxy-8-methoxy-3-p-tolyl-6H-benzo[c]chromen-6-one 
• 1420293-48-6 4-((4-chlorophenyl)thio)-4-(p-tolyl)butan-2-one 
• 1504566-56-6 4-(4-methylphenyl)-4-(p-toluenesulfonyl)-2-butanone 
• 17220-04-1 2,5-dimethyl-4-(p-tolyl)pyridine 

Relevant articles and documents

Green sustainable approach for carbon–carbon bond-forming reactions using FeNPs/DETA@rGO nano-catalyst

We have fabricated eccentric highly persuasive bifunctional FeNPs/DETA@rGO (where DETA = diethylenetriamine) nano-catalyst with a dual activation mechanism by presenting aliphatic amine on the basal and/or edges sites offering a base characteristic and Fe

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention of autophagy. Post-translational modifications like acetylation of Lys49 on the LIR-interacting surface could disrupt the interaction, offering an opportunity to design covalent small molecules interfering with the interface. Through screening covalent compounds, we discovered a small molecule modulator of LC3A/B that covalently modifies LC3A/B protein at Lys49. Activity-based protein profiling (ABPP) based evaluations reveal that a derivative molecule DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells. DC-LC3in-D5 compromises LC3B lipidation in vitro and in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation. DC-LC3in-D5 could serve as a powerful tool for autophagy research as well as for therapeutic interventions.

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.