402473-54-5 Usage
Description
ONO-AE3-208 is a prostaglandin E receptor EP4 antagonist, a type of chemical compound that has been found to have significant potential in the field of cancer research and treatment. It functions by inhibiting the activity of the prostaglandin E receptor EP4, which is often associated with the progression and metastasis of certain types of cancer, particularly breast cancer.
Uses
Used in Pharmaceutical Industry:
ONO-AE3-208 is used as an anticancer agent for its ability to inhibit breast cancer metastasis. By targeting the prostaglandin E receptor EP4, it can potentially limit the spread of cancer cells to other parts of the body, making it a valuable tool in the fight against breast cancer.
Additionally, due to its mechanism of action, ONO-AE3-208 may also have applications in other cancer types that involve the prostaglandin E receptor EP4. However, further research would be required to confirm its effectiveness in these contexts.
Biological Activity
ono-ae3-208 is an antagonist of ep4 [1].ep4 is one of the prostaglandin e2 receptors and is associated with inflammatory disease and cancer such as prostate cancer. as an antagonist of ep4, ono-ae3-208 is expected to be a potential therapy for prostate cancer. in vitro assays show that ono-ae3-208 can suppress the migration and invasion of prostate cancer cells. 10μm of ono-ae3-208 decreases wound healing proportion of pc3 and lncap cell lines in wound-healing assay. and in transwell invasion assay, ono-ae3-208 inhibits cell invasion even at concentration of 0.1μm. ono-ae3-208 is also reported to suppress bone metastasis in vivo [1].since activation of e2 can increase the expression of matrix metalloproteinase (mmp) and release inflammatory cytokines, and then exacerbates abdominal aortic aneurism (aaa) formation, ono-ae3-208 is also used in the studies of aaa formation. it has been proved that ono-ae3-208 can cause the elastic fiber degradation and inhibit aaa formation in vivo in a dose-dependent manner [2].
references
[1] song xu, zhengyu zhang, osamu ogawa,takeshi yoshikawa, hiromasa sakamoto, noboru shibasaki, akayuki goto, liming wang, naoki terada. an ep4 antagonist ono-ae3-208 suppresses cell invasion, migration and metastasis of prostate cancer. cell biochem biophys. 2014, april.[2] utako yokoyama, ryo ishiwata, mei-hua jin, yuko kato, orie suzuki, huiling jin, yasuhiro ichikawa, syun kumagaya, yuzo katayama, takayuki fujita, satoshi okumura, motohiko sato, yukihiko sugimoto, hiroki aoki, shinichi suzuki, munetaka masuda, susumu minamisawa, yoshihiro ishikawa. inhibition of ep4 signaling attenuates aortic aneurysm formation. plos one. 2012, may. 7, 5, e36724.
Check Digit Verification of cas no
The CAS Registry Mumber 402473-54-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,2,4,7 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 402473-54:
(8*4)+(7*0)+(6*2)+(5*4)+(4*7)+(3*3)+(2*5)+(1*4)=115
115 % 10 = 5
So 402473-54-5 is a valid CAS Registry Number.
402473-54-5Relevant articles and documents
Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
-
, (2008/06/13)
A carboxylic acid derivative of formula (1) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; Rsup